Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 13/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | JAK1 | P23458 | 1/20 | 0.43 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7043841 | 0.87 | MAPT (0.51) | PDE10APDE4DTSHRJAK1HSP90AB1 | |
| SCHEMBL6876513 | 0.86 | PDE4D (0.48) | PDE10APDE4DJAK1 | |
| SCHEMBL7146570 | 0.86 | PDE4D (0.48) | PDE10APDE4DTSHRJAK1 | |
| SCHEMBL2250839 | 0.85 | PDE4D (0.64) | PDE10APDE4DJAK1HSP90AB1 | |
| SCHEMBL7144538 | 0.84 | PDE4D (0.49) | PDE10APDE4DJAK1HSP90AB1HPGD | |
| SCHEMBL7150018 | 0.83 | DYRK3 (0.47) | PDE10APDE4DTSHRHPGDHSD17B10 | |
| SCHEMBL7041043 | 0.82 | PDE4D (0.46) | PDE4DTSHRJAK1HSP90AB1POLB | |
| SCHEMBL7146861 | 0.82 | PDE4D (0.70) | PDE4D | |
| SCHEMBL7144542 | 0.79 | PDE4D (0.53) | PDE4DPOLB | |
| SCHEMBL7043078 | 0.79 | JAK1 (0.60) | PDE10APDE4DMAPK1JAK1HSP90AB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6514989-B1 | Has a good affinity to the adenosine receptor and can therefore be used for the treatment or protection of diseases mediated by this receptor | HOFFMANN-LA ROCHE INC. | 2003-02-04 | — | — | US | disclosed |