Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB3 | P13945 | 13/20 | 0.42 |
| ▸ | F2 | P00734 | 3/20 | 0.40 |
| ▸ | F10 | P00742 | 3/20 | 0.40 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.40 |
| ▸ | F7 | P08709 | 3/20 | 0.40 |
| ▸ | ADRB2 | P07550 | 5/20 | 0.39 |
| ▸ | ADRB1 | P08588 | 4/20 | 0.39 |
| ▸ | ESRRA | P11474 | 1/20 | 0.39 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.38 |
| ▸ | F3 | P13726 | 1/20 | 0.38 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.38 |
| ▸ | CTSV | O60911 | 1/20 | 0.38 |
| ▸ | CTSL | P07711 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7036245 | 0.89 | ADRB3 (0.42) | ADRB3F2F10PRSS1F7 | |
| SCHEMBL6986483 | 0.82 | ADRB3 (0.48) | ADRB3F2F10PRSS1F7 | |
| SCHEMBL7038384 | 0.81 | ADRB3 (0.60) | ADRB3ADRB2ADRB1 | |
| SCHEMBL7038435 | 0.78 | ADRB3 (0.52) | ADRB3ADRB2ADRB1 | |
| SCHEMBL7038441 | 0.78 | ADRB3 (0.52) | ADRB3ADRB2ADRB1 | |
| SCHEMBL4817546 | 0.77 | CYP19A1 (0.44) | ADRB3F2F10PRSS1F7 | |
| SCHEMBL6479480 | 0.77 | CYP19A1 (0.44) | ADRB3F2F10PRSS1F7 | |
| SCHEMBL5483348 | 0.77 | CYP19A1 (0.44) | ADRB3F2F10PRSS1F7 | |
| SCHEMBL7605339 | 0.77 | CYP19A1 (0.44) | ADRB3F2F10PRSS1F7 | |
| SCHEMBL7605348 | 0.77 | CYP19A1 (0.44) | ADRB3F2F10PRSS1F7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0659737-B1 | Catecholamine surrogates useful as beta 3 agonists | BRISTOL MYERS SQUIBB CO (US) | 2003-03-26 | — | — | EP | disclosed |
| EP-0659737-A2 | Catecholamine surrogates useful as B3 agonists | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-06-28 | — | — | EP | disclosed |