Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCKBR | P32239 | 12/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | CCKAR | P32238 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.42 |
| ▸ | RELA | Q04206 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8083313 | 0.92 | CCKBR (0.53) | CCKBRKCNH2ALDH1A1TP53MEN1 | |
| SCHEMBL8614108 | 0.82 | KCNH2 (0.47) | CCKBRKCNH2ALDH1A1TP53MEN1 | |
| SCHEMBL7044669 | 0.77 | CCKBR (0.51) | CCKBRKCNH2CCKAR | |
| SCHEMBL8084127 | 0.76 | KCNH2 (0.52) | CCKBRKCNH2ALDH1A1TP53MEN1 | |
| SCHEMBL7046124 | 0.76 | CCKBR (0.49) | CCKBRKCNH2CCKARHPGD | |
| SCHEMBL4417220 | 0.75 | PSEN1 (0.59) | CCKBRCCKAR | |
| SCHEMBL8760297 | 0.74 | KCNH2 (0.78) | CCKBRKCNH2CCKAR | |
| SCHEMBL8761581 | 0.74 | KCNH2 (0.78) | CCKBRKCNH2CCKAR | |
| SCHEMBL8745232 | 0.72 | KCNH2 (0.57) | CCKBRKCNH2ALDH1A1TP53MEN1 | |
| SCHEMBL8761291 | 0.70 | KCNH2 (0.70) | CCKBRKCNH2CCKAR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0842156-B1 | NOVEL N-(2,4-DIOXO-2,3,4,5-TETRAHYDRO-1H-1,5-BENZODIAZEPIN-3YL)-3-AMIDES | MERCK & CO INC (US) | 2003-04-09 | — | — | EP | claimed |
| EP-0842156-A4 | NOVEL N-(2,4-DIOXO-2,3,4,5-TETRAHYDRO-1H-1,5-BENZODIAZEPIN-3YL)-3-AMIDES | MERCK & CO INC (US) | 1998-11-11 | — | — | EP | claimed |
| EP-0842156-A1 | NOVEL N-(2,4-DIOXO-2,3,4,5-TETRAHYDRO-1H-1,5-BENZODIAZEPIN-3YL)-3-AMIDES | Merck & Co., Inc. (US) | 1998-05-20 | — | — | EP | claimed |
| US-5700797-A | N-(2,4-dioxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-3-yl)-3-amides | MERCK & CO, INC. (US) | 1997-12-23 | — | — | US | claimed |
| WO-1996040654-A1 | NOVEL N-(2,4-DIOXO-2,3,4,5-TETRAHYDRO-1H-1,5-BENZODIAZEPIN-3YL)-3-AMIDES | MERCK & CO., INC. (US) | 1996-12-19 | — | — | WO | claimed |
| EP-0842156-B1 | NOVEL N-(2,4-DIOXO-2,3,4,5-TETRAHYDRO-1H-1,5-BENZODIAZEPIN-3YL)-3-AMIDES | MERCK & CO INC (US) | 2003-04-09 | — | — | EP | disclosed |
| EP-0842156-A4 | NOVEL N-(2,4-DIOXO-2,3,4,5-TETRAHYDRO-1H-1,5-BENZODIAZEPIN-3YL)-3-AMIDES | MERCK & CO INC (US) | 1998-11-11 | — | — | EP | disclosed |
| EP-0842156-A1 | NOVEL N-(2,4-DIOXO-2,3,4,5-TETRAHYDRO-1H-1,5-BENZODIAZEPIN-3YL)-3-AMIDES | Merck & Co., Inc. (US) | 1998-05-20 | — | — | EP | disclosed |
| US-5700797-A | N-(2,4-dioxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-3-yl)-3-amides | MERCK & CO, INC. (US) | 1997-12-23 | — | — | US | disclosed |
| WO-1996040654-A1 | NOVEL N-(2,4-DIOXO-2,3,4,5-TETRAHYDRO-1H-1,5-BENZODIAZEPIN-3YL)-3-AMIDES | MERCK & CO., INC. (US) | 1996-12-19 | — | — | WO | disclosed |