SCHEMBL8083313

SCHEMBL8083313

CC(C)N1C(=O)C(NC(=O)CCC2CCCCC2)C(=O)N(C(C)C)c2ccccc21

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CCKBR P32239 1/20 0.53
KCNH2 Q12809 1/20 0.51
ALDH1A1 P00352 7/20 0.48
NPC1 O15118 5/20 0.48
HPGD P15428 4/20 0.48
SMN1; SMN2 Q16637 4/20 0.48
RAB9A P51151 4/20 0.48
NFKB1 P19838 1/20 0.48
NFKB2 Q00653 1/20 0.48
RELA Q04206 1/20 0.48
HSD17B10 Q99714 1/20 0.48
TP53 P04637 2/20 0.46
MEN1 O00255 4/20 0.46
KMT2A Q03164 4/20 0.46
TDP1 Q9NUW8 1/20 0.46
HTT P42858 2/20 0.44
NPSR1 Q6W5P4 1/20 0.44
OPRM1 P35372 1/20 0.43
OPRL1 P41146 1/20 0.43
CYP1A2 P05177 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7044153 0.92 CCKBR (0.50) CCKBRKCNH2ALDH1A1NPC1HPGD
SCHEMBL8084127 0.81 KCNH2 (0.52) CCKBRKCNH2ALDH1A1NPC1HPGD
SCHEMBL8760297 0.78 KCNH2 (0.78) CCKBRKCNH2
SCHEMBL8761581 0.78 KCNH2 (0.78) CCKBRKCNH2
SCHEMBL8745232 0.78 KCNH2 (0.57) CCKBRKCNH2ALDH1A1NPC1HPGD
SCHEMBL8760312 0.77 KCNH2 (0.63) CCKBRKCNH2
SCHEMBL8761291 0.75 KCNH2 (0.70) CCKBRKCNH2
SCHEMBL8614108 0.75 KCNH2 (0.47) CCKBRKCNH2ALDH1A1NPC1HPGD
SCHEMBL8075698 0.73 KCNH2 (0.44) CCKBRKCNH2TSHR
SCHEMBL7206914 0.73 KCNH2 (0.52) CCKBRKCNH2ALDH1A1NPC1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0832075-B1 N-(2,4-DIOXO-2,3,4,5-TETRAHYDRO-1H-1,5-BENZODIAZEPIN-3Y L)-3-AMIDES MERCK & CO INC (US) 2000-10-11 EP claimed
EP-0832075-A4 NOVEL N-(2,4-DIOXO-2,3,4,5-TETRAHYDRO-1H-1,5-BENZODIAZEPIN-3Y L)-3-AMIDES MERCK & CO INC (US) 1998-10-07 EP claimed
EP-0832075-A1 NOVEL N-(2,4-DIOXO-2,3,4,5-TETRAHYDRO-1H-1,5-BENZODIAZEPIN-3Y L)-3-AMIDES Merck & Co., Inc. (US) 1998-04-01 EP claimed
US-5691331-A N-(2,4-Dioxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-3yl) -3- amides MERCK & CO., INC. (US) 1997-11-25 US claimed
WO-1996040655-A1 NOVEL N-(2,4-DIOXO-2,3,4,5-TETRAHYDRO-1H-1,5-BENZODIAZEPIN-3Y L)-3-AMIDES MERCK & CO., INC. (US) 1996-12-19 WO claimed
EP-0832075-B1 N-(2,4-DIOXO-2,3,4,5-TETRAHYDRO-1H-1,5-BENZODIAZEPIN-3Y L)-3-AMIDES MERCK & CO INC (US) 2000-10-11 EP disclosed
EP-0832075-A4 NOVEL N-(2,4-DIOXO-2,3,4,5-TETRAHYDRO-1H-1,5-BENZODIAZEPIN-3Y L)-3-AMIDES MERCK & CO INC (US) 1998-10-07 EP disclosed
EP-0832075-A1 NOVEL N-(2,4-DIOXO-2,3,4,5-TETRAHYDRO-1H-1,5-BENZODIAZEPIN-3Y L)-3-AMIDES Merck & Co., Inc. (US) 1998-04-01 EP disclosed
US-5691331-A N-(2,4-Dioxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-3yl) -3- amides MERCK & CO., INC. (US) 1997-11-25 US disclosed
WO-1996040655-A1 NOVEL N-(2,4-DIOXO-2,3,4,5-TETRAHYDRO-1H-1,5-BENZODIAZEPIN-3Y L)-3-AMIDES MERCK & CO., INC. (US) 1996-12-19 WO disclosed