SCHEMBL7044486

SCHEMBL7044486

CCn1c(C2CCCNC2)nc2c(OC(N)=O)cccc21

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRM1 P11229 3/20 0.44
HRH1 P35367 2/20 0.44
PARP1 P09874 8/20 0.41
PARP2 Q9UGN5 4/20 0.39
PARP3 Q9Y6F1 3/20 0.39
TNKS O95271 1/20 0.39
CHRM2 P08172 1/20 0.39
SLC6A2 P23975 1/20 0.39
SLC6A4 P31645 1/20 0.39
ADRA1A P35348 1/20 0.39
SLC6A3 Q01959 1/20 0.39
KCNH2 Q12809 1/20 0.39
DYRK1A Q13627 1/20 0.39
PARP15 Q460N3 1/20 0.39
PARP14 Q460N5 1/20 0.39
PARP10 Q53GL7 1/20 0.39
PARP12 Q9H0J9 1/20 0.39
TNKS2 Q9H2K2 1/20 0.39
PARP4 Q9UKK3 1/20 0.39
DYRK1B Q9Y463 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7043328 0.94 JAK2 (0.40) CHRM1HRH1PARP1PARP2PARP3
SCHEMBL7043993 0.89 CHRM1 (0.46) CHRM1HRH1PARP1PARP2PARP3
SCHEMBL7041213 0.89 CHRM1 (0.46) CHRM1HRH1PARP1PARP2PARP3
SCHEMBL7045696 0.89 CHRM1 (0.48) CHRM1HRH1PARP1PARP2PARP3
SCHEMBL7039421 0.88 CHRM1 (0.44) CHRM1HRH1PARP1PARP2PARP3
SCHEMBL7041855 0.88 JAK2 (0.46) HRH1PARP1PARP2IKBKB
SCHEMBL7042453 0.87 CHRM1 (0.44) CHRM1HRH1PARP1PARP2PARP3
SCHEMBL7044663 0.86 CHRM1 (0.44) CHRM1HRH1PARP1PARP2PARP3
SCHEMBL7041163 0.85 TAAR1 (0.41) PARP1PARP2PARP3OPRL1
SCHEMBL5620635 0.85 PARP1 (0.55) CHRM1HRH1PARP1PARP2PARP3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1133477-B1 SUBSTITUTED BENZIMIDAZOLES AND THEIR USE AS PARP INHIBITORS ABBOTT GMBH & CO KG (DE) 2004-02-18 EP disclosed