Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 3/20 | 0.40 |
| ▸ | JAK1 | P23458 | 3/20 | 0.40 |
| ▸ | TYK2 | P29597 | 3/20 | 0.40 |
| ▸ | JAK3 | P52333 | 3/20 | 0.40 |
| ▸ | PARP1 | P09874 | 9/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.37 |
| ▸ | HRH1 | P35367 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | PARP2 | Q9UGN5 | 3/20 | 0.33 |
| ▸ | PARP3 | Q9Y6F1 | 3/20 | 0.33 |
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.33 |
| ▸ | TNKS | O95271 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7044486 | 0.94 | CHRM1 (0.44) | PARP1CHRM1HRH1PARP2PARP3 | |
| SCHEMBL7041855 | 0.94 | JAK2 (0.46) | JAK2JAK1TYK2JAK3PARP1 | |
| SCHEMBL7044226 | 0.89 | JAK2 (0.51) | JAK2JAK1TYK2JAK3PARP1 | |
| SCHEMBL7041387 | 0.89 | JAK2 (0.42) | JAK2JAK1TYK2JAK3PARP1 | |
| SCHEMBL7044268 | 0.88 | HRH1 (0.41) | JAK2JAK1TYK2JAK3PARP1 | |
| SCHEMBL7044872 | 0.88 | JAK2 (0.39) | JAK2JAK1TYK2JAK3PARP1 | |
| SCHEMBL7043077 | 0.86 | PARP1 (0.44) | JAK2JAK1TYK2JAK3PARP1 | |
| SCHEMBL7042457 | 0.85 | JAK2 (0.39) | JAK2JAK1TYK2JAK3PARP1 | |
| SCHEMBL7042033 | 0.85 | NPY1R (0.40) | JAK2JAK1TYK2JAK3PARP1 | |
| SCHEMBL5621424 | 0.84 | PARP1 (0.54) | JAK2JAK1TYK2JAK3PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1133477-B1 | SUBSTITUTED BENZIMIDAZOLES AND THEIR USE AS PARP INHIBITORS | ABBOTT GMBH & CO KG (DE) | 2004-02-18 | — | — | EP | disclosed |