Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KA3 | P51812 | 13/20 | 0.49 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.43 |
| ▸ | NUDT1 | P36639 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | GCGR | P47871 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7045431 | 0.84 | RPS6KA3 (0.55) | RPS6KA3LIMK1NUDT1KDM4EALDH1A1 | |
| SCHEMBL6729132 | 0.78 | RPS6KA3 (0.44) | RPS6KA3LIMK1NUDT1KDM4EALDH1A1 | |
| SCHEMBL6736780 | 0.77 | RPS6KA3 (0.51) | RPS6KA3LIMK1NUDT1KDM4EALDH1A1 | |
| SCHEMBL6744643 | 0.73 | RPS6KA3 (0.56) | RPS6KA3CYP17A1 | |
| SCHEMBL6735505 | 0.70 | NR1H2 (0.43) | RPS6KA3LIMK1NUDT1KDM4EALDH1A1 | |
| SCHEMBL6646252 | 0.68 | CYP19A1 (0.55) | RPS6KA3KDM4ESMN1; SMN2GCGRMAPK14 | |
| SCHEMBL6744647 | 0.68 | RPS6KA3 (0.63) | RPS6KA3CYP17A1 | |
| SCHEMBL7111626 | 0.68 | RPS6KA3 (0.46) | RPS6KA3 | |
| SCHEMBL7396406 | 0.67 | SLC22A12 (0.54) | RPS6KA3LIMK1MAPK14CYP17A1KDR | |
| SCHEMBL6729704 | 0.67 | RPS6KA3 (0.44) | RPS6KA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1296971-A2 | 2-FLUOROBENZENESULFONYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | Pharmacia Corporation (US) | 2003-04-02 | — | — | EP | disclosed |
| WO-2001081332-A2 | 2-FLUOROBENZENESULFONYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | PHARMACIA CORPORATION (US) | 2001-11-01 | — | — | WO | disclosed |