Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KA3 | P51812 | 17/20 | 0.56 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.48 |
| ▸ | RPS6KA2 | Q15349 | 2/20 | 0.41 |
| ▸ | RPS6KA1 | Q15418 | 2/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.40 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6744647 | 0.85 | RPS6KA3 (0.63) | RPS6KA3SLC22A12RPS6KA2RPS6KA1CYP11B2 | |
| SCHEMBL6736797 | 0.80 | SLC22A12 (0.58) | RPS6KA3SLC22A12CYP17A1 | |
| SCHEMBL7396406 | 0.80 | SLC22A12 (0.54) | RPS6KA3SLC22A12CYP11B2CYP17A1CYP3A4 | |
| SCHEMBL7545909 | 0.76 | SLC22A12 (0.57) | RPS6KA3SLC22A12 | |
| SCHEMBL6719208 | 0.75 | SLC22A12 (0.50) | RPS6KA3SLC22A12CYP11B2CYP17A1CYP3A4 | |
| SCHEMBL7045425 | 0.73 | RPS6KA3 (0.49) | RPS6KA3CYP17A1 | |
| SCHEMBL7396409 | 0.73 | SLC22A12 (0.57) | RPS6KA3SLC22A12CYP11B2CYP17A1CYP3A4 | |
| SCHEMBL7045431 | 0.70 | RPS6KA3 (0.55) | RPS6KA3CYP17A1 | |
| SCHEMBL1770133 | 0.70 | CYP11B2 (0.51) | RPS6KA3SLC22A12CYP11B2CYP17A1CYP3A4 | |
| SCHEMBL20365105 | 0.70 | SLC22A12 (0.50) | RPS6KA3SLC22A12CYP11B2CYP17A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6699884-B2 | ANTIINFLAMMATORY CYCLOOXYGENASE INHIBITORS. | PHARMACIA CORPORATION | 2004-03-02 | — | — | US | claimed |