Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 8/20 | 0.67 |
| ▸ | ROCK1 | Q13464 | 7/20 | 0.67 |
| ▸ | PRKCE | Q02156 | 3/20 | 0.67 |
| ▸ | PRKCD | Q05655 | 3/20 | 0.67 |
| ▸ | PRKD1 | Q15139 | 3/20 | 0.67 |
| ▸ | PRKX | P51817 | 2/20 | 0.67 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.58 |
| ▸ | MYLK | Q15746 | 3/20 | 0.58 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.58 |
| ▸ | MEN1 | O00255 | 3/20 | 0.58 |
| ▸ | TP53 | P04637 | 2/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 3/20 | 0.57 |
| ▸ | GMNN | O75496 | 2/20 | 0.57 |
| ▸ | TSHR | P16473 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7049151 | 0.88 | ROCK2 (0.71) | ROCK2ROCK1PRKCEPRKCDPRKD1 | |
| SCHEMBL7047822 | 0.86 | ROCK2 (0.68) | ROCK2ROCK1PRKCEPRKCDPRKD1 | |
| SCHEMBL31399681 | 0.85 | ROCK2 (0.59) | ROCK2ROCK1PRKCEPRKCDPRKD1 | |
| SCHEMBL31399766 | 0.83 | ROCK2 (0.63) | ROCK2ROCK1PRKCEPRKCDPRKD1 | |
| SCHEMBL13513878 | 0.83 | ROCK2 (0.77) | ROCK2ROCK1PRKCEPRKCDPRKD1 | |
| SCHEMBL7811565 | 0.83 | ROCK2 (0.51) | ROCK2ROCK1PRKCEPRKCDPRKD1 | |
| SCHEMBL7807378 | 0.82 | ROCK2 (0.62) | ROCK2ROCK1PRKCEPRKCDPRKD1 | |
| SCHEMBL31399751 | 0.81 | ROCK2 (0.59) | ROCK2ROCK1PRKCEPRKCDPRKD1 | |
| Hydroxyfasudil SCHEMBL1827528 | 0.80 | ROCK2 (0.75) | ROCK2ROCK1PRKCEPRKCDPRKD1 | |
| SCHEMBL6845278 | 0.80 | ROCK2 (1.00) | ROCK2ROCK1PRKCEPRKCDPRKD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040266755-A1 | Prodrugs of 1-(1-hydroxy-5-isoquinolinesulfonyl) homopiperazine | SCHERING AKTIENGESELLSCHAFT (DE) | 2004-12-30 | — | — | US | claimed |
| WO-2004106325-A1 | PRODRUGS OF 1-(1-HYDROXY-5-ISOQUINOLINESULFONYL)HOMOPIPERAZINE | SCHERING AKTIENGESELLSCHAFT (DE) | 2004-12-09 | — | — | WO | claimed |
| US-20040266755-A1 | Prodrugs of 1-(1-hydroxy-5-isoquinolinesulfonyl) homopiperazine | SCHERING AKTIENGESELLSCHAFT (DE) | 2004-12-30 | — | — | US | disclosed |
| WO-2004106325-A1 | PRODRUGS OF 1-(1-HYDROXY-5-ISOQUINOLINESULFONYL)HOMOPIPERAZINE | SCHERING AKTIENGESELLSCHAFT (DE) | 2004-12-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040266755-A1 | Prodrugs of 1-(1-hydroxy-5-isoquinolinesulfonyl) homopiperazine | HTR5A, CYP2S1, CYP3A5 | ROCK2 3996/4885ROCK1 2844/4885PRKCE 4513/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.