Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.37 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.37 |
| ▸ | GRIA2 | P42262 | 2/20 | 0.37 |
| ▸ | GRIA4 | P48058 | 2/20 | 0.37 |
| ▸ | GRIK3 | Q13003 | 2/20 | 0.37 |
| ▸ | GRIK5 | Q16478 | 2/20 | 0.37 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.37 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 4/20 | 0.35 |
| ▸ | MGAM | O43451 | 1/20 | 0.35 |
| ▸ | SI | P14410 | 1/20 | 0.35 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4661591 | 0.85 | GAA (0.50) | SMN1; SMN2ALDH1A1CYP2D6EGLN1NPSR1 | |
| SCHEMBL12162469 | 0.82 | GRIK1 (0.40) | ALDH1A1EGLN1GRIK1GRIA2GRIA4 | |
| SCHEMBL1405553 | 0.82 | GRIK1 (0.40) | ALDH1A1EGLN1GRIK1GRIA2GRIA4 | |
| SCHEMBL28464075 | 0.82 | GRIK1 (0.35) | ALDH1A1GRIK1GRIA2GRIA4GRIK3 | |
| SCHEMBL1597248 | 0.80 | ALDH1A1 (0.50) | SMN1; SMN2ALDH1A1CYP2D6EGLN1NPSR1 | |
| SCHEMBL9241910 | 0.79 | GRIK1 (0.38) | GRIK1GRIA2GRIA4GRIK3GRIK5 | |
| SCHEMBL28448521 | 0.79 | NPSR1 (0.38) | SMN1; SMN2ALDH1A1CYP2D6EGLN1NPSR1 | |
| SCHEMBL5963307 | 0.79 | ALDH1A1 (0.43) | SMN1; SMN2ALDH1A1CYP2D6EGLN1NPSR1 | |
| SCHEMBL5963310 | 0.79 | ALDH1A1 (0.43) | SMN1; SMN2ALDH1A1CYP2D6EGLN1NPSR1 | |
| SCHEMBL28326056 | 0.78 | KDM4E (0.36) | GRIK1GRIA2GRIA4GRIK3GRIK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1042270-B1 | ASYMMETRIC HYDROGENATION | CHIROTECH TECHNOLOGY LTD (GB) | 2003-04-09 | — | — | EP | disclosed |
| US-6207853-B1 | SUCCINIC ACID DERIVATIVE | CHIROTECH TECHNOLOGY, INC. (GB) | 2001-03-27 | — | — | US | disclosed |
| EP-1042270-A1 | ASYMMETRIC HYDROGENATION | Chirotech Technology Limited (GB) | 2000-10-11 | — | — | EP | disclosed |
| WO-1999031041-A1 | ASYMMETRIC HYDROGENATION | CHIROTECH TECHNOLOGY LIMITED (GB) | 1999-06-24 | — | — | WO | disclosed |
| US-4918105-A | Novel compounds with collagenase-inhibiting activity, a process for their preparation and pharmaceutical compositions in which these compounds are present | SA LABORATOIRE ROGER BELLON (FR) | 1990-04-17 | — | — | US | disclosed |