Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.42 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.41 |
| ▸ | GSK3A | P49840 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | DHODH | Q02127 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | GALR2 | O43603 | 1/20 | 0.40 |
| ▸ | MITF | O75030 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | XBP1 | P17861 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11638792 | 0.83 | MAPT (0.47) | KDM4EMAPTGAASLC9A1PDE7A | |
| SCHEMBL9064586 | 0.82 | MAPT (0.44) | KDM4EMAPTGAASLC9A1LMNA | |
| SCHEMBL16198090 | 0.82 | KCNMA1 (0.38) | MAPTGSK3AGSK3BLMNADHODH | |
| SCHEMBL11641252 | 0.81 | MAPT (0.45) | KDM4EMAPTGAASLC9A1PDE7A | |
| SCHEMBL8530875 | 0.78 | KDM4E (0.56) | KDM4EHSD17B10MAPTALDH1A1POLB | |
| SCHEMBL8904042 | 0.77 | AR (0.43) | KDM4EMAPTGAAPDE7ALMNA | |
| SCHEMBL2049036 | 0.76 | TSHR (0.56) | DHODHKCNMA1ALDH1A1HPGDKDM1A | |
| SCHEMBL31636358 | 0.76 | TSHR (0.56) | DHODHKCNMA1ALDH1A1HPGDKDM1A | |
| SCHEMBL1494608 | 0.76 | CYP3A4 (0.52) | HSD17B10ALDH1A1HPGD | |
| SCHEMBL5110430 | 0.76 | TSHR (0.59) | KDM4EMAPTGAALMNAKCNMA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003007959-A1 | QUINOXALINE DERIVATIVES WHICH HAVE PARP INHIBITORY ACTION | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-01-30 | — | — | WO | disclosed |