Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | JAK1 | P23458 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.45 |
| ▸ | STS | P08842 | 1/20 | 0.45 |
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 2/20 | 0.42 |
| ▸ | CA2 | P00918 | 2/20 | 0.42 |
| ▸ | CA4 | P22748 | 2/20 | 0.42 |
| ▸ | CA9 | Q16790 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.41 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2943387 | 0.88 | CA1 (0.54) | JAK2JAK1MAPK1GPR119STS | |
| SCHEMBL17058 | 0.88 | CA1 (0.54) | JAK2JAK1MAPK1GPR119STS | |
| SCHEMBL3494790 | 0.88 | CA1 (0.54) | JAK2JAK1MAPK1GPR119STS | |
| SCHEMBL778413 | 0.87 | NAMPT (0.47) | JAK2JAK1MAPK1GPR119 | |
| SCHEMBL13705105 | 0.87 | MAPT (0.44) | JAK2JAK1GPR119 | |
| SCHEMBL8235884 | 0.87 | JAK2 (0.45) | JAK2JAK1MAPK1GPR119STS | |
| SCHEMBL12090083 | 0.84 | JAK2 (0.46) | JAK2JAK1MAPK1GPR119STS | |
| SCHEMBL13705091 | 0.81 | LTA4H (0.46) | JAK2JAK1MAPK1GPR119STS | |
| SCHEMBL8115259 | 0.81 | MAPK1 (0.46) | JAK2JAK1MAPK1GPR119STS | |
| SCHEMBL15645152 | 0.81 | LTA4H (0.46) | JAK2JAK1MAPK1GPR119STS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030073681-A1 | 2-substituted piperidines that are ligands for monoamine receptors and transporters | SEPRACOR INC. | 2003-04-17 | — | — | US | disclosed |
| WO-2003016274-A2 | 2-SUBSTITUTED PIPERIDINES THAT ARE LIGANDS FOR MONOAMINE RECEPTORS AND TRANSPORTERS | SEPRACOR, INC. (US) | 2003-02-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030073681-A1 | 2-substituted piperidines that are ligands for monoamine receptors and transporters | HTR2C, HTR5A, HTR2A | JAK2 751/4885JAK1 3247/4885MAPK1 3607/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.