Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 4/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.52 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | CCR2 | P41597 | 5/20 | 0.38 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.37 |
| ▸ | RGS4 | P49798 | 1/20 | 0.36 |
| ▸ | RGS8 | P57771 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7050842 | 0.89 | HDAC1 (0.48) | HDAC1HDAC6LMNAMAPTRAB9A | |
| SCHEMBL7045478 | 0.87 | HDAC1 (0.47) | HDAC1HDAC6LMNAMAPTRAB9A | |
| SCHEMBL7954546 | 0.86 | HDAC1 (0.46) | HDAC1HDAC6LMNAMAPTRAB9A | |
| SCHEMBL7048313 | 0.86 | HDAC1 (0.52) | HDAC1HDAC6LMNAMAPTRAB9A | |
| SCHEMBL7050230 | 0.85 | HDAC1 (0.45) | HDAC1HDAC6LMNAMAPTRAB9A | |
| SCHEMBL7046362 | 0.84 | HDAC1 (0.51) | HDAC1HDAC6LMNAMAPTRAB9A | |
| SCHEMBL7050364 | 0.77 | HDAC1 (0.42) | HDAC1HDAC6LMNAMAPTRAB9A | |
| SCHEMBL7049001 | 0.77 | SMN1; SMN2 (0.45) | HDAC1HDAC6LMNAMAPTRAB9A | |
| SCHEMBL7048128 | 0.75 | CCR2 (0.45) | LMNAMAPTRAB9ASMN1; SMN2GAA | |
| SCHEMBL7050359 | 0.75 | HDAC1 (0.40) | HDAC1HDAC6LMNAMAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1054667-B1 | BICYCLIC PYRROLE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE AS ANTIINFLAMMATORY AND IMMUNOMODULATING AGENTS | ASTRAZENECA UK LTD (GB) | 2003-04-16 | — | — | EP | disclosed |
| US-6291507-B1 | INHIBITOR OF MONOCYTE CHEMOATTRACTANT PROTEIN-1; INDOLE DERIVATIVES | ASTRAZENECA UK LIMITED (GB) | 2001-09-18 | — | — | US | disclosed |