Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 3/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.47 |
| ▸ | CCR2 | P41597 | 4/20 | 0.41 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.40 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.40 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.40 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 4/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HPD | P32754 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.38 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7050842 | 0.89 | HDAC1 (0.48) | HDAC1HDAC6CCR2CSNK2A2CSNK2B | |
| SCHEMBL7048131 | 0.87 | HDAC1 (0.52) | HDAC1HDAC6CCR2RAB9ALMNA | |
| SCHEMBL7954546 | 0.86 | HDAC1 (0.46) | HDAC1HDAC6CCR2CSNK2A2CSNK2B | |
| SCHEMBL7050230 | 0.85 | HDAC1 (0.45) | HDAC1HDAC6CCR2CSNK2A2CSNK2B | |
| SCHEMBL7048313 | 0.83 | HDAC1 (0.52) | HDAC1HDAC6CCR2CSNK2A2CSNK2B | |
| SCHEMBL7047694 | 0.82 | BRD4 (0.50) | HDAC1HDAC6CCR2RAB9ANPC1 | |
| SCHEMBL7046362 | 0.80 | HDAC1 (0.51) | HDAC1HDAC6CCR2RAB9ALMNA | |
| SCHEMBL7045477 | 0.76 | CCR2 (0.44) | CCR2RAB9ALMNAMAPTGAA | |
| SCHEMBL7050364 | 0.74 | HDAC1 (0.42) | HDAC1HDAC6CCR2RAB9ALMNA | |
| SCHEMBL7049001 | 0.72 | SMN1; SMN2 (0.45) | HDAC1HDAC6RAB9ALMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1054667-B1 | BICYCLIC PYRROLE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE AS ANTIINFLAMMATORY AND IMMUNOMODULATING AGENTS | ASTRAZENECA UK LTD (GB) | 2003-04-16 | — | — | EP | disclosed |
| US-6291507-B1 | INHIBITOR OF MONOCYTE CHEMOATTRACTANT PROTEIN-1; INDOLE DERIVATIVES | ASTRAZENECA UK LIMITED (GB) | 2001-09-18 | — | — | US | disclosed |