Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.89 |
| ▸ | MAPT | P10636 | 5/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.70 |
| ▸ | MEN1 | O00255 | 4/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.70 |
| ▸ | LMNA | P02545 | 1/20 | 0.70 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.64 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.64 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.64 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.62 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.60 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.55 |
| ▸ | FNTA | P49354 | 1/20 | 0.55 |
| ▸ | FNTB | P49356 | 1/20 | 0.55 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.53 |
| ▸ | KLK6 | Q92876 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL361312 | 0.94 | PKM (1.00) | PKMMAPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL30419025 | 0.94 | PKM (1.00) | PKMMAPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL31613108 | 0.86 | PKM (0.70) | PKMMAPTSMN1; SMN2MEN1KMT2A | |
| Indole-3-Acetic Acid SCHEMBL7887240 | 0.85 | MEN1 (0.75) | PKMMAPTSMN1; SMN2MEN1KMT2A | |
| Indole-3-Acetic Acid SCHEMBL26344 | 0.85 | MEN1 (0.75) | PKMMAPTSMN1; SMN2MEN1KMT2A | |
| Indole-3-Acetic Acid SCHEMBL29350750 | 0.85 | MEN1 (0.75) | PKMMAPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL11186814 | 0.85 | MAPT (0.78) | PKMMAPTSMN1; SMN2MEN1KMT2A | |
| Indole-3-Acetic Acid SCHEMBL468233 | 0.84 | MEN1 (0.73) | PKMMAPTSMN1; SMN2MEN1KMT2A | |
| Indole-3-Acetic Acid SCHEMBL11125791 | 0.84 | MEN1 (0.73) | PKMMAPTSMN1; SMN2MEN1KMT2A | |
| Indole-3-Acetic Acid SCHEMBL1375190 | 0.84 | MEN1 (0.73) | PKMMAPTSMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1476151-A1 | 1-ARYLSULFONYL-3-SUBSTITUED INDOLE AND INDOLINE DERIVATES USEFUL IN THE TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS | Akzo Nobel N.V. (NL) | 2004-11-17 | — | — | EP | disclosed |
| WO-2003068220-A1 | 1-ARYLSULFONYL-3-SUBSTITUTED INDOLE AND INDOLINE DERIVATIVES USEFUL IN THE TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS | AKZO NOBEL N.V. (NL) | 2003-08-21 | — | — | WO | disclosed |