Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 1/20 | 0.40 |
| ▸ | TNK2 | Q07912 | 3/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.39 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 6/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | ITGB3 | P05106 | 3/20 | 0.39 |
| ▸ | ITGAV | P06756 | 3/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7048334 | 1.00 | GRIN2B (0.40) | GRIN2BTNK2MAPK8MAPK9L3MBTL1 | |
| SCHEMBL6459707 | 0.89 | GRIN2B (0.43) | GRIN2BTNK2MAPK8MAPK9MCHR1 | |
| SCHEMBL6459705 | 0.89 | GRIN2B (0.43) | GRIN2BTNK2MAPK8MAPK9MCHR1 | |
| SCHEMBL6463839 | 0.81 | MCHR1 (0.60) | TNK2L3MBTL1MCHR1ADRA2AADRA1A | |
| SCHEMBL6463836 | 0.81 | MCHR1 (0.60) | TNK2L3MBTL1MCHR1ADRA2AADRA1A | |
| SCHEMBL6456570 | 0.80 | MCHR1 (0.60) | MCHR1ADRA2AADRA1AHRH1HTR2B | |
| SCHEMBL6456564 | 0.80 | MCHR1 (0.60) | MCHR1ADRA2AADRA1AHRH1HTR2B | |
| SCHEMBL6867773 | 0.78 | ALDH1A1 (0.54) | MAPK8MAPK9 | |
| SCHEMBL6880526 | 0.78 | MCHR1 (0.40) | GRIN2BL3MBTL1MCHR1ADRA2AADRA1A | |
| SCHEMBL6873725 | 0.77 | MCHR1 (0.52) | MCHR1ADRA2AADRA1AHRH1HTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |