Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Benzotriazole. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | PKM | P14618 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 2/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | CDK1 | P06493 | 1/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.36 |
| ▸ | MASP2 | O00187 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzotriazole SCHEMBL28239991 | 0.95 | ALDH1A1 (0.38) | ALDH1A1KDM4ENPC1RAB9APKM | |
| Benzotriazole SCHEMBL11428495 | 0.95 | ALDH1A1 (0.38) | ALDH1A1KDM4ENPC1RAB9APKM | |
| Benzotriazole SCHEMBL6141636 | 0.95 | ALDH1A1 (0.38) | ALDH1A1KDM4ENPC1RAB9APKM | |
| Benzotriazole SCHEMBL8956 | 0.95 | — | — | |
| Benzotriazole SCHEMBL6088869 | 0.95 | ALDH1A1 (0.41) | ALDH1A1KDM4ENPC1RAB9APKM | |
| Benzotriazole SCHEMBL29381270 | 0.95 | — | — | |
| SCHEMBL20445532 | 0.93 | ALDH1A1 (0.39) | ALDH1A1KDM4ENPC1RAB9APKM | |
| Benzotriazole SCHEMBL1987805 | 0.93 | ALDH1A1 (0.39) | ALDH1A1KDM4ENPC1RAB9APKM | |
| Benzotriazole SCHEMBL9275781 | 0.93 | ALDH1A1 (0.39) | ALDH1A1KDM4ENPC1RAB9APKM | |
| Benzotriazole SCHEMBL1019155 | 0.93 | ALDH1A1 (0.39) | ALDH1A1KDM4ENPC1RAB9APKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0851282-B1 | Processing of a light-sensitive silver halide photographic material | AGFA GEVAERT (BE) | 2003-04-16 | — | — | EP | disclosed |
| US-5912108-A | FORMING IMAGES BY EXPOSURE TO LIGHT ON SUPPORTS | AGFA-GEVAERT, N.V. (BE) | 1999-06-15 | — | — | US | disclosed |
| EP-0851282-A1 | Processing of a light-sensitive silver halide photographic material | AGFA-GEVAERT N.V. (BE) | 1998-07-01 | — | — | EP | disclosed |