Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G1B | P04054 | 19/20 | 0.86 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.59 |
| ▸ | PLA2G5 | P39877 | 1/20 | 0.54 |
| ▸ | PLA2G2E | Q9NZK7 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7046992 | 0.92 | PLA2G1B (1.00) | PLA2G1BPLA2G2APLA2G5PLA2G2E | |
| SCHEMBL8319422 | 0.88 | PLA2G1B (0.85) | PLA2G1BPLA2G2APLA2G5PLA2G2E | |
| SCHEMBL7014687 | 0.87 | PLA2G1B (0.87) | PLA2G1BPLA2G2APLA2G5PLA2G2E | |
| SCHEMBL7011983 | 0.84 | PLA2G1B (0.85) | PLA2G1BPLA2G2APLA2G5PLA2G2E | |
| SCHEMBL8322145 | 0.83 | PLA2G1B (0.74) | PLA2G1BPLA2G2APLA2G5PLA2G2E | |
| SCHEMBL8071903 | 0.83 | PLA2G1B (0.59) | PLA2G1BPLA2G2A | |
| SCHEMBL7144875 | 0.82 | PLA2G1B (0.86) | PLA2G1BPLA2G2APLA2G5PLA2G2E | |
| SCHEMBL7008239 | 0.81 | PLA2G1B (0.85) | PLA2G1BPLA2G2APLA2G5PLA2G2E | |
| SCHEMBL7016234 | 0.80 | PLA2G1B (1.00) | PLA2G1BPLA2G2APLA2G5PLA2G2E | |
| SCHEMBL8028219 | 0.80 | PLA2G1B (0.55) | PLA2G1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030149000-A1 | Method for the treatment of disorders associated with apoptosis using N-heterocyclic glyoxylamide compounds | SHIONOGI & CO., LTD. | 2003-08-07 | — | — | US | claimed |
| US-6214855-B1 | AFTERTREATMENT OF STROKE | SHIONOGI & CO., LTD. (JP) | 2001-04-10 | — | — | US | claimed |
| WO-1999024033-A1 | METHOD FOR THE TREATMENT OF DISORDERS ASSOCIATED WITH APOPTOSIS USING N-HETEROCYCLIC GLYOXYLAMIDE COMPOUNDS | SHIONOGI & CO., LTD. (JP) | 1999-05-20 | — | — | WO | claimed |
| US-20030149000-A1 | Method for the treatment of disorders associated with apoptosis using N-heterocyclic glyoxylamide compounds | SHIONOGI & CO., LTD. | 2003-08-07 | — | — | US | disclosed |
| US-6214855-B1 | AFTERTREATMENT OF STROKE | SHIONOGI & CO., LTD. (JP) | 2001-04-10 | — | — | US | disclosed |
| WO-1999024033-A1 | METHOD FOR THE TREATMENT OF DISORDERS ASSOCIATED WITH APOPTOSIS USING N-HETEROCYCLIC GLYOXYLAMIDE COMPOUNDS | SHIONOGI & CO., LTD. (JP) | 1999-05-20 | — | — | WO | disclosed |
| EP-0772596-A4 | INDOLIZINE sPLA2 INHIBITORS | LILLY CO ELI (US) | 1999-01-13 | — | — | EP | disclosed |
| EP-0772596-A1 | INDOLIZINE sPLA2 INHIBITORS | ELI LILLY AND COMPANY (US) | 1997-05-14 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030149000-A1 | Method for the treatment of disorders associated with apoptosis using N-heterocyclic glyoxylamide compounds | BAX, CASP3, CASP5 | PLA2G1B 2849/4885PLA2G2A 3271/4885PLA2G5 2065/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.