Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.52 |
| ▸ | CCKBR | P32239 | 17/20 | 0.51 |
| ▸ | CCKAR | P32238 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8075666 | 0.93 | KCNH2 (0.55) | KCNH2CCKBRALDH1A1 | |
| SCHEMBL7045631 | 0.89 | KCNH2 (0.53) | KCNH2CCKBRCCKAR | |
| SCHEMBL7046124 | 0.85 | CCKBR (0.49) | KCNH2CCKBRCCKAR | |
| SCHEMBL8075702 | 0.83 | ALDH1A1 (0.49) | KCNH2CCKBRALDH1A1 | |
| SCHEMBL7861646 | 0.83 | KCNH2 (0.50) | KCNH2CCKBRALDH1A1 | |
| SCHEMBL7046218 | 0.80 | CCKBR (0.55) | KCNH2CCKBRCCKARALDH1A1 | |
| SCHEMBL7046314 | 0.78 | KCNH2 (0.61) | KCNH2CCKBRCCKAR | |
| SCHEMBL7817780 | 0.78 | KCNH2 (0.55) | KCNH2CCKBRALDH1A1 | |
| SCHEMBL8075815 | 0.77 | KCNH2 (0.59) | KCNH2CCKBRALDH1A1 | |
| SCHEMBL8075665 | 0.77 | KCNH2 (0.49) | KCNH2CCKBRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0842156-B1 | NOVEL N-(2,4-DIOXO-2,3,4,5-TETRAHYDRO-1H-1,5-BENZODIAZEPIN-3YL)-3-AMIDES | MERCK & CO INC (US) | 2003-04-09 | — | — | EP | claimed |
| EP-0842156-B1 | NOVEL N-(2,4-DIOXO-2,3,4,5-TETRAHYDRO-1H-1,5-BENZODIAZEPIN-3YL)-3-AMIDES | MERCK & CO INC (US) | 2003-04-09 | — | — | EP | disclosed |
| EP-0842156-A4 | NOVEL N-(2,4-DIOXO-2,3,4,5-TETRAHYDRO-1H-1,5-BENZODIAZEPIN-3YL)-3-AMIDES | MERCK & CO INC (US) | 1998-11-11 | — | — | EP | disclosed |
| EP-0842156-A1 | NOVEL N-(2,4-DIOXO-2,3,4,5-TETRAHYDRO-1H-1,5-BENZODIAZEPIN-3YL)-3-AMIDES | Merck & Co., Inc. (US) | 1998-05-20 | — | — | EP | disclosed |
| US-5700797-A | N-(2,4-dioxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-3-yl)-3-amides | MERCK & CO, INC. (US) | 1997-12-23 | — | — | US | disclosed |
| WO-1996040654-A1 | NOVEL N-(2,4-DIOXO-2,3,4,5-TETRAHYDRO-1H-1,5-BENZODIAZEPIN-3YL)-3-AMIDES | MERCK & CO., INC. (US) | 1996-12-19 | — | — | WO | disclosed |