Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.48 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 3/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | TTR | P02766 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HTR1D | P28221 | 1/20 | 0.39 |
| ▸ | ELANE | P08246 | 1/20 | 0.38 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.38 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27842773 | 0.79 | LMNA (0.41) | LMNAACHECYP3A4KDM4EGAA | |
| SCHEMBL27784137 | 0.75 | GLA (0.40) | LMNAACHECYP3A4KDM4EGAA | |
| SCHEMBL2010436 | 0.73 | LMNA (0.59) | LMNAACHECYP3A4KDM4EGAA | |
| SCHEMBL28577024 | 0.71 | LMNA (0.50) | LMNAACHECYP3A4KDM4EGAA | |
| SCHEMBL1701666 | 0.70 | LMNA (0.63) | LMNAACHECYP3A4KDM4EGAA | |
| SCHEMBL593772 | 0.70 | LMNA (0.63) | LMNAACHECYP3A4KDM4EGAA | |
| SCHEMBL28793573 | 0.68 | LMNA (0.61) | LMNAACHECYP3A4KDM4EGAA | |
| SCHEMBL6364662 | 0.68 | LMNA (0.52) | LMNAACHECYP3A4KDM4EGAA | |
| SCHEMBL269329 | 0.68 | LMNA (0.80) | LMNAACHECYP3A4KDM4EGAA | |
| SCHEMBL23809728 | 0.67 | BACE1 (0.52) | LMNAACHECYP3A4KDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6677368-B2 | 4-aryl substituted indolinones | SUGEN, INC. | 2004-01-13 | — | — | US | disclosed |