Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP3 | O14638 | 15/20 | 0.37 |
| ▸ | ENPP1 | P22413 | 13/20 | 0.37 |
| ▸ | ENPP2 | Q13822 | 10/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5036686 | 0.91 | SMN1; SMN2 (0.41) | ENPP3ENPP1ENPP2NPC1POLB | |
| SCHEMBL5037680 | 0.88 | ENPP3 (0.44) | ENPP3ENPP1ENPP2NPC1POLB | |
| SCHEMBL5036477 | 0.83 | SMN1; SMN2 (0.42) | ENPP3ENPP1ENPP2NPC1POLB | |
| SCHEMBL5040851 | 0.82 | SMN1; SMN2 (0.46) | ENPP3ENPP1ENPP2NPC1POLB | |
| SCHEMBL5037853 | 0.82 | TERT (0.42) | ENPP3ENPP1ENPP2MAPTSMN1; SMN2 | |
| SCHEMBL5036151 | 0.81 | SMN1; SMN2 (0.40) | ENPP3ENPP1ENPP2NPC1POLB | |
| SCHEMBL5036583 | 0.80 | SMN1; SMN2 (0.43) | ENPP3ENPP1ENPP2NPC1POLB | |
| SCHEMBL5042929 | 0.80 | SMN1; SMN2 (0.44) | ENPP3ENPP1ENPP2NPC1POLB | |
| SCHEMBL5033505 | 0.80 | SMN1; SMN2 (0.44) | ENPP3ENPP1ENPP2NPC1POLB | |
| SCHEMBL5036234 | 0.80 | SMN1; SMN2 (0.42) | ENPP3ENPP1ENPP2MAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1432417-A2 | SUBSTITUTED BENZIMIDAZOLE COMPOUNDS AND THEIR USE FOR THE TREATMENT OF CANCER | Aventis Pharma S.A. (FR) | 2004-06-30 | — | — | EP | disclosed |
| WO-2003028721-A2 | SUBSTITUTED BENZIMIDAZOLE COMPOUNDS AND THEIR USE FOR THE TREATMENT OF CANCER | AVENTIS PHARMA S.A. (FR) | 2003-04-10 | — | — | WO | disclosed |