Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.66 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.66 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | PLEC | Q15149 | 1/20 | 0.41 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.41 |
| ▸ | PPARA | Q07869 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24403947 | 0.85 | MAPT (0.61) | MAPTTDP1SMN1; SMN2L3MBTL1ALDH1A1 | |
| SCHEMBL13623664 | 0.85 | ATM (0.46) | MAPTTDP1ATMSMN1; SMN2L3MBTL1 | |
| SCHEMBL10740176 | 0.84 | ATM (0.49) | MAPTTDP1ATMSMN1; SMN2L3MBTL1 | |
| SCHEMBL7701905 | 0.82 | ALDH1A1 (0.53) | MAPTATMSMN1; SMN2L3MBTL1ALDH1A1 | |
| SCHEMBL8960208 | 0.81 | MAPT (0.61) | MAPTTDP1ATMSMN1; SMN2L3MBTL1 | |
| SCHEMBL8399254 | 0.81 | MAPT (0.61) | MAPTTDP1L3MBTL1NPC1RAB9A | |
| SCHEMBL11884043 | 0.81 | ALDH1A1 (0.53) | MAPTTDP1ATMSMN1; SMN2L3MBTL1 | |
| SCHEMBL11352711 | 0.80 | MAPT (0.59) | MAPTTDP1SMN1; SMN2L3MBTL1ALDH1A1 | |
| SCHEMBL27939427 | 0.80 | HSD17B3 (0.57) | MAPTTDP1ATMALDH1A1HTT | |
| SCHEMBL13783388 | 0.79 | MAPT (0.76) | MAPTTDP1SMN1; SMN2L3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015004481-A1 | IMIDAZO-CONDENSED BICYCLES AS INHIBITORS OF DISCOIDIN DOMAIN RECEPTORS (DDRS) | ASTEX THERAPEUTICS LIMITED (GB) | 2015-01-15 | — | — | WO | disclosed |
| WO-2015004481-A1 | IMIDAZO-CONDENSED BICYCLES AS INHIBITORS OF DISCOIDIN DOMAIN RECEPTORS (DDRS) | ASTEX THERAPEUTICS LIMITED (GB) | 2015-01-15 | — | — | WO | disclosed |
| CN-102633783-A | Benzazole derivatives, compositions, and methods of use as aurora kinase inhibitors | TRANSTECH PHARMA INC | 2012-08-15 | — | — | CN | disclosed |
| CN-101379060-B | Benzoxazole-based derivatives as Aurora kinase inhibitors, compositions, and methods of use | TRANSTECH PHARMA INC | 2012-05-23 | — | — | CN | disclosed |
| CN-101379060-A | Benzoxazole-based derivatives as Aurora kinase inhibitors, compositions, and methods of use | TRANSTECH PHARMA INC (US) | 2009-03-04 | — | — | CN | disclosed |
| EP-0609885-B1 | Acridinium compounds and conjugates thereof | MOCHIDA PHARM CO LTD (JP) | 2003-04-16 | — | — | EP | disclosed |
| US-5594112-A | CHEMILUMINESCENCE LABEL | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 1997-01-14 | — | — | US | disclosed |
| US-5438139-A | Chemiluminescent; useful as immunolochemical, DNA probe and receptor bininding assays | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 1995-08-01 | — | — | US | disclosed |
| EP-0609885-A1 | Acridinium compounds and conjugates thereof | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 1994-08-10 | — | — | EP | disclosed |