Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 17/20 | 0.61 |
| ▸ | SLC6A3 | Q01959 | 16/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.61 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.61 |
| ▸ | TSHR | P16473 | 2/20 | 0.61 |
| ▸ | TP53 | P04637 | 1/20 | 0.61 |
| ▸ | SLC6A2 | P23975 | 8/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.46 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.46 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.46 |
| ▸ | HTR2B | P41595 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5668946 | 1.00 | SLC6A4 (0.61) | SLC6A4SLC6A3CYP3A4ALOX15TSHR | |
| SCHEMBL5661116 | 1.00 | SLC6A4 (0.61) | SLC6A4SLC6A3CYP3A4ALOX15TSHR | |
| Fumaric Acid SCHEMBL9864056 | 0.90 | SLC6A4 (0.51) | SLC6A4SLC6A3CYP3A4ALOX15TSHR | |
| Maleic Acid SCHEMBL9864047 | 0.90 | SLC6A4 (0.51) | SLC6A4SLC6A3CYP3A4ALOX15TSHR | |
| SCHEMBL9864319 | 0.89 | SLC6A4 (0.58) | SLC6A4SLC6A3CYP3A4ALOX15TSHR | |
| SCHEMBL9863950 | 0.87 | SLC6A4 (0.61) | SLC6A4SLC6A3CYP3A4ALOX15TSHR | |
| SCHEMBL9863883 | 0.86 | CYP3A4 (0.63) | SLC6A4SLC6A3CYP3A4ALOX15TSHR | |
| SCHEMBL9863419 | 0.86 | SLC6A4 (0.56) | SLC6A4SLC6A3CYP3A4ALOX15TSHR | |
| SCHEMBL9864044 | 0.86 | SLC6A4 (0.62) | SLC6A4SLC6A3CYP3A4ALOX15TSHR | |
| SCHEMBL9863736 | 0.85 | TP53 (0.43) | SLC6A4SLC6A3CYP3A4ALOX15TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030087963-A1 | Methods of preparing and using 2-hydroxy derivatives of sibutramine and its metabolites | SEPRACOR, INC. | 2003-05-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030087963-A1 | Methods of preparing and using 2-hydroxy derivatives of sibutramine and its metabolites | HTR5A, HTR4, HTR1B | SLC6A4 21/4885SLC6A3 38/4885CYP3A4 189/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.