Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES1 | P23141 | 12/20 | 0.45 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.41 |
| ▸ | NSD2 | O96028 | 1/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.38 |
| ▸ | DAO | P14920 | 1/20 | 0.38 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.32 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.32 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.32 |
| ▸ | TGM2 | P21980 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7050415 | 1.00 | CES1 (0.45) | CES1DNMT1NSD2BCHEDAO | |
| SCHEMBL7052625 | 0.87 | CES1 (0.41) | CES1DNMT1NSD2BCHEDAO | |
| SCHEMBL7052629 | 0.87 | CES1 (0.41) | CES1DNMT1NSD2BCHEDAO | |
| SCHEMBL7048387 | 0.82 | TSHR (0.42) | CES1DNMT1NSD2BCHEDAO | |
| SCHEMBL7048389 | 0.82 | TSHR (0.42) | CES1DNMT1NSD2BCHEDAO | |
| SCHEMBL7051894 | 0.79 | UCHL3 (0.38) | CES1DNMT1NSD2BCHEDAO | |
| SCHEMBL7049846 | 0.77 | CES1 (0.65) | CES1DNMT1NSD2BCHEDAO | |
| SCHEMBL7049842 | 0.77 | CES1 (0.65) | CES1DNMT1NSD2BCHEDAO | |
| SCHEMBL7048414 | 0.74 | CES1 (0.46) | CES1DNMT1TGM2 | |
| SCHEMBL7048416 | 0.74 | CES1 (0.46) | CES1DNMT1TGM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0706396-B1 | 1,2,3,4-TETRAHYDROQUINOLINE-2,3,4-TRIONE-3 OR 4-OXIMES AND USE | OREGON STATE (US) | 2003-05-02 | — | — | EP | disclosed |
| US-5652368-A | NERVOUS SYSTEM DISORDERS, ALZHEIMER'S DISEASE | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1997-07-29 | — | — | US | disclosed |
| US-5475007-A | Preventing convulsions | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1995-12-12 | — | — | US | disclosed |