Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 13/20 | 1.00 |
| ▸ | NOS3 | P29474 | 7/20 | 1.00 |
| ▸ | NOS1 | P29475 | 7/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6662711 | 0.83 | NOS2 (0.70) | NOS2NOS3NOS1 | |
| SCHEMBL10264860 | 0.79 | NOS2 (0.65) | NOS2NOS3NOS1 | |
| SCHEMBL7769935 | 0.77 | NOS2 (0.63) | NOS2NOS3NOS1 | |
| SCHEMBL105871 | 0.77 | — | — | |
| SCHEMBL4547885 | 0.76 | NOS2 (0.61) | NOS2NOS3NOS1 | |
| SCHEMBL12015758 | 0.74 | NOS2 (0.59) | NOS2NOS3NOS1 | |
| SCHEMBL15980614 | 0.73 | NOS3 (0.57) | NOS2NOS3NOS1 | |
| SCHEMBL18611537 | 0.73 | NOS3 (0.57) | NOS2NOS3NOS1 | |
| SCHEMBL9228677 | 0.73 | NOS2 (0.57) | NOS2NOS3NOS1 | |
| SCHEMBL16282388 | 0.73 | NOS3 (0.57) | NOS2NOS3NOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003013523-A1 | SH3 PROTEIN DOMAINS AND THEIR LIGANDS | ADELAIDE RESEARCH & INNOVATION PTY LTD (AU) | 2003-02-20 | — | — | WO | claimed |
| US-5972975-A | Substituted 2-aminopyridines as inhibitors of nitric oxide synthase | MERCK & CO., INC. (US) | 1999-10-26 | — | — | US | claimed |
| WO-1996018616-A1 | SUBSTITUTED 2-AMINOPYRIDINES AS INHIBITORS OF NITRIC OXIDE SYNTHASE | MERCK & CO., INC. (US) | 1996-06-20 | — | — | WO | claimed |
| EP-4041714-B1 | BI-ARYL DIHYDROOROTATE DEHYDROGENASE INHIBITORS | JANSSEN BIOTECH INC (US) | 2023-12-13 | — | — | EP | disclosed |
| WO-2021239058-A1 | FUSED TRICYCLIC COMPOUND, PHARMACEUTICAL COMPOSITION THEREOF, AND USE THEREOF | 劲方医药科技(上海)有限公司 | 2021-12-02 | — | — | WO | disclosed |
| US-20210355125-A1 | HETEROCYCLIC COMPOUNDS, PREPARATION METHODS AND USES THEREOF | InventisBio Co., Ltd. (CN) | 2021-11-18 | — | — | US | disclosed |
| US-11091481-B2 | Heterocyclic compounds, preparation and methods and uses thereof | InventisBio Co., Ltd. (CN) | 2021-08-17 | — | — | US | disclosed |
| US-20210198255-A1 | HETEROCYCLIC COMPOUNDS, PREPARATION AND METHODS AND USES THEREOF | InventisBio Co., Ltd. (CN) | 2021-07-01 | — | — | US | disclosed |
| WO-2020233592-A1 | HETEROCYCLIC COMPOUNDS, PREPARATION METHODS AND USES THEREOF | INVENTISBIO SHANGHAI LTD. (CN) | 2020-11-26 | — | — | WO | disclosed |
| EP-2802567-B1 | PYRIDAZINE AMIDE COMPOUNDS AND THEIR USE AS SYK INHIBITORS | HOFFMANN LA ROCHE (CH) | 2017-03-01 | — | — | EP | disclosed |
| CN-104159891-B | Pyridazine amide compound and they are as the purposes of SYK inhibitor | 霍夫曼-拉罗奇有限公司 | 2016-09-07 | — | — | CN | disclosed |
| US-8901124-B2 | Pyridazine amide compounds useful as SYK inhibitors | HOFFMANN-LA ROCHE INC. (US) | 2014-12-02 | — | — | US | disclosed |
| EP-2802567-A1 | PYRIDAZINE AMIDE COMPOUNDS AND THEIR USE AS SYK INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2014-11-19 | — | — | EP | disclosed |
| CN-104159891-A | Pyridazine amide compounds and their use as SYK inhibitors | HOFFMANN LA ROCHE | 2014-11-19 | — | — | CN | disclosed |
| WO-2013104573-A1 | PYRIDAZINE AMIDE COMPOUNDS AND THEIR USE AS SYK INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2013-07-18 | — | — | WO | disclosed |
| US-20130178478-A1 | PYRIDAZINE AMIDE COMPOUNDS | HOFFMAN-LA ROCHE INC. (US) | 2013-07-11 | — | — | US | disclosed |
| WO-2003013523-A1 | SH3 PROTEIN DOMAINS AND THEIR LIGANDS | ADELAIDE RESEARCH & INNOVATION PTY LTD (AU) | 2003-02-20 | — | — | WO | disclosed |
| US-5972975-A | Substituted 2-aminopyridines as inhibitors of nitric oxide synthase | MERCK & CO., INC. (US) | 1999-10-26 | — | — | US | disclosed |
| WO-1996018616-A1 | SUBSTITUTED 2-AMINOPYRIDINES AS INHIBITORS OF NITRIC OXIDE SYNTHASE | MERCK & CO., INC. (US) | 1996-06-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11091481-B2 | Heterocyclic compounds, preparation and methods and uses thereof | KRAS, NRAS, HRAS | NOS2 4520/4885NOS3 4605/4885NOS1 4458/4885 |
| US-20130178478-A1 | PYRIDAZINE AMIDE COMPOUNDS | SYK, BTK, IRAK2 | NOS2 618/4885NOS3 1138/4885NOS1 861/4885 |
| US-20210355125-A1 | HETEROCYCLIC COMPOUNDS, PREPARATION METHODS AND USES THEREOF | KRAS, NRAS, HRAS | NOS2 4365/4885NOS3 4496/4885NOS1 4279/4885 |
| US-20210198255-A1 | HETEROCYCLIC COMPOUNDS, PREPARATION AND METHODS AND USES THEREOF | KRAS, NRAS, HRAS | NOS2 4520/4885NOS3 4605/4885NOS1 4458/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.