Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL9 | O00512 | 1/20 | 0.46 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 5/20 | 0.45 |
| ▸ | CRHBP | P24387 | 1/20 | 0.45 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | MGLL | Q99685 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7050818 | 1.00 | BCL9 (0.46) | BCL9CTNNB1MAPTCRHBPCRHR2 | |
| SCHEMBL6978503 | 0.85 | BCL9 (0.52) | BCL9CTNNB1MAPTCRHBPCRHR2 | |
| SCHEMBL7050815 | 0.76 | BCL9 (0.57) | BCL9CTNNB1MAPTCRHBPCRHR2 | |
| SCHEMBL8746385 | 0.74 | TSHR (0.67) | MAPTKMT2AALDH1A1GAASMN1; SMN2 | |
| SCHEMBL27083890 | 0.74 | TSHR (0.67) | MAPTKMT2AALDH1A1GAASMN1; SMN2 | |
| SCHEMBL14275292 | 0.74 | GAA (0.54) | BCL9CTNNB1MAPTKMT2AALDH1A1 | |
| SCHEMBL14275297 | 0.74 | GAA (0.54) | BCL9CTNNB1MAPTKMT2AALDH1A1 | |
| SCHEMBL27818621 | 0.73 | MGLL (0.52) | BCL9CTNNB1MAPTCRHBPCRHR2 | |
| SCHEMBL10024490 | 0.73 | BCL9 (0.59) | BCL9CTNNB1MAPTCRHBPCRHR2 | |
| SCHEMBL18966687 | 0.73 | MAPT (0.48) | BCL9CTNNB1MAPTCRHBPCRHR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1029869-B1 | Endothelin converting enzyme inhibitors | WELLCOME FOUND (GB) | 2003-04-23 | — | — | EP | disclosed |
| US-6235717-B1 | Pharmaceutical compounds | GLAXO WELLCOME INC. | 2001-05-22 | — | — | US | disclosed |
| EP-1029869-A1 | Endothelin converting enzyme inhibitors | THE WELLCOME FOUNDATION LIMITED (GB) | 2000-08-23 | — | — | EP | disclosed |
| EP-0677059-A1 | ENDOTHELIN CONVERTING ENZYME INHIBITORS | THE WELLCOME FOUNDATION LIMITED (GB) | 1995-10-18 | — | — | EP | disclosed |
| WO-1994015956-A1 | ENDOTHELIN CONVERTING ENZYME INHIBITORS | THE WELLCOME FOUNDATION LIMITED (GB) | 1994-07-21 | — | — | WO | disclosed |