Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.67 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.49 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27083890 | 1.00 | TSHR (0.67) | TSHRMAPTEPHX1ADORA3ALDH1A1 | |
| SCHEMBL8942583 | 0.85 | TSHR (0.62) | TSHRMAPTADORA3ALDH1A1LMNA | |
| SCHEMBL9691641 | 0.84 | EPHX1 (0.52) | TSHRMAPTEPHX1ADORA3ALDH1A1 | |
| SCHEMBL2210689 | 0.82 | TSHR (0.79) | TSHRMAPTEPHX1ALDH1A1LMNA | |
| SCHEMBL9527149 | 0.81 | EPHX1 (0.49) | TSHREPHX1ALDH1A1LMNAKMT2A | |
| SCHEMBL8875725 | 0.81 | TSHR (1.00) | TSHRMAPTEPHX1ALDH1A1SMN1; SMN2 | |
| SCHEMBL14365934 | 0.81 | TSHR (1.00) | TSHRMAPTEPHX1ALDH1A1SMN1; SMN2 | |
| SCHEMBL14393160 | 0.81 | TSHR (1.00) | TSHRMAPTEPHX1ALDH1A1SMN1; SMN2 | |
| SCHEMBL8746347 | 0.81 | TSHR (1.00) | TSHRMAPTEPHX1ALDH1A1SMN1; SMN2 | |
| SCHEMBL3201023 | 0.81 | TSHR (1.00) | TSHRMAPTEPHX1ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0654026-B1 | ISOSERINE DERIVATIVES AND THEIR USE AS LEUKOTRIENE ANTAGONISTS | LEO PHARM PROD LTD (DK) | 1997-02-19 | — | — | EP | disclosed |
| US-5576438-A | LIPOXYGENASE INHIBITORS; ANTIALLERGENS, ANTIINFLAMMATORY AGENTS | Leo Pharmaceutical Products Ltd. A/S (L.o slashed.vens Kemiske Fabrik Produktionsaktiesel Skab) (DK) | 1996-11-19 | — | — | US | disclosed |
| EP-0654026-A1 | ISOSERINE DERIVATIVES AND THEIR USE AS LEUKOTRIENE ANTAGONISTS. | LEO PHARM PROD LTD (DK) | 1995-05-24 | — | — | EP | disclosed |
| WO-1994003431-A1 | ISOSERINE DERIVATIVES AND THEIR USE AS LEUKOTRIENE ANTAGONISTS | Leo Pharmaceutical Products Ltd. A/S (Løvens Kemiske Fabrik Produktionsaktieselskab) (DK) | 1994-02-17 | — | — | WO | disclosed |