Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 2/20 | 0.46 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.41 |
| ▸ | ESR1 | P03372 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | GALR3 | O60755 | 1/20 | 0.40 |
| ▸ | ADRB3 | P13945 | 8/20 | 0.39 |
| ▸ | ADRB1 | P08588 | 4/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7051162 | 1.00 | OPRK1 (0.46) | OPRK1ADRB2LMNAESR2ESR1 | |
| SCHEMBL7058088 | 0.87 | ADRB3 (0.43) | ADRB2ADRB3ADRB1 | |
| SCHEMBL7058823 | 0.83 | ADRB3 (0.45) | ADRB2ADRB3ADRB1 | |
| SCHEMBL7058826 | 0.83 | ADRB3 (0.45) | ADRB2ADRB3ADRB1 | |
| Hydrochloric Acid SCHEMBL7054734 | 0.82 | ADRB3 (0.59) | ADRB2CYP2C9ADRB3ADRB1 | |
| Hydrochloric Acid SCHEMBL7057667 | 0.80 | ADRB3 (0.45) | ADRB2ADRB3ADRB1 | |
| SCHEMBL7056462 | 0.79 | ADRB3 (0.44) | ADRB2ADRB3ADRB1 | |
| SCHEMBL8076934 | 0.79 | ADRB3 (0.44) | ADRB2ADRB3ADRB1 | |
| SCHEMBL7051952 | 0.77 | ADRB3 (0.46) | ADRB2CYP3A4CYP2C9HIF1AADRB3 | |
| SCHEMBL7051954 | 0.77 | ADRB3 (0.46) | ADRB2CYP3A4CYP2C9HIF1AADRB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0940387-B1 | PHENYLETHANOLAMINE COMPOUNDS USEFUL AS BETA3 AGONIST, PROCESS FOR PRODUCING THE SAME, AND INTERMEDIATES IN THE PRODUCTION OF THE SAME | MITSUBISHI PHARMA CORP (JP) | 2003-05-07 | — | — | EP | disclosed |
| US-6069176-A | PHENYLETHANOLAMINE COMPOUNDS WITH A BETA-3 ADRENERGIC RECEPTOR STIMULATING EFFECT, USE AS A THERAPY FOR URINARY INCONTINENCE | MITSUBISHI-TOKYO PHARMACEUTICALS, INC. (JP) | 2000-05-30 | — | — | US | disclosed |
| EP-0940387-A1 | PHENYLETHANOLAMINE COMPOUNDS USEFUL AS BETA3 AGONIST, PROCESS FOR PRODUCING THE SAME, AND INTERMEDIATES IN THE PRODUCTION OF THE SAME | TOKYO TANABE COMPANY LIMITED (JP) | 1999-09-08 | — | — | EP | disclosed |