Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.39 |
| ▸ | HPGD | P15428 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | F2 | P00734 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | TGM2 | P21980 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | CES1 | P23141 | 3/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7051654 | 0.91 | KMT2A (0.39) | KMT2AHPGDALDH1A1F2ATM | |
| SCHEMBL7051535 | 0.87 | CES1 (0.48) | KMT2AHPGDALDH1A1F2ATM | |
| SCHEMBL8871643 | 0.86 | MAPT (0.38) | KMT2AHPGDALDH1A1F2ATM | |
| SCHEMBL7051070 | 0.86 | MAPT (0.38) | KMT2AHPGDALDH1A1F2ATM | |
| SCHEMBL7054835 | 0.83 | CES1 (0.47) | KMT2AHPGDALDH1A1F2ATM | |
| SCHEMBL7054180 | 0.82 | HPGD (0.37) | KMT2AHPGDALDH1A1F2ATM | |
| SCHEMBL7053378 | 0.82 | CES1 (0.39) | ALDH1A1TGM2MAPTCES1LMNA | |
| SCHEMBL7051548 | 0.80 | CES1 (0.48) | KMT2AHPGDALDH1A1F2ATM | |
| SCHEMBL7054980 | 0.80 | MAPT (0.38) | KMT2AHPGDALDH1A1F2ATM | |
| SCHEMBL7051552 | 0.79 | CES1 (0.47) | KMT2AHPGDALDH1A1F2ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0706396-B1 | 1,2,3,4-TETRAHYDROQUINOLINE-2,3,4-TRIONE-3 OR 4-OXIMES AND USE | OREGON STATE (US) | 2003-05-02 | — | — | EP | disclosed |
| US-5652368-A | NERVOUS SYSTEM DISORDERS, ALZHEIMER'S DISEASE | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1997-07-29 | — | — | US | disclosed |