Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES1 | P23141 | 5/20 | 0.39 |
| ▸ | UCHL3 | P15374 | 4/20 | 0.34 |
| ▸ | UCHL1 | P09936 | 4/20 | 0.34 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.33 |
| ▸ | CDK1 | P06493 | 2/20 | 0.33 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.33 |
| ▸ | GSK3A | P49840 | 2/20 | 0.33 |
| ▸ | GSK3B | P49841 | 2/20 | 0.33 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.33 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.33 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.33 |
| ▸ | TGM2 | P21980 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7048302 | 0.90 | CES1 (0.36) | CES1UCHL3UCHL1CCNB2CDK1 | |
| SCHEMBL7047393 | 0.85 | CES1 (0.54) | CES1UCHL3UCHL1CCNB2CDK1 | |
| SCHEMBL7052308 | 0.85 | TSHR (0.36) | CES1UCHL3UCHL1CCNB2CDK1 | |
| SCHEMBL7050080 | 0.85 | CES1 (0.33) | CES1UCHL3UCHL1CCNB2CDK1 | |
| SCHEMBL7051545 | 0.82 | KMT2A (0.39) | CES1TGM2ALDH1A1LMNAMAPT | |
| SCHEMBL7050695 | 0.81 | CES1 (0.53) | CES1UCHL3UCHL1CCNB2CDK1 | |
| SCHEMBL7052827 | 0.80 | CES1 (0.38) | CES1UCHL3UCHL1CCNB2CDK1 | |
| SCHEMBL7051894 | 0.79 | UCHL3 (0.38) | CES1UCHL3UCHL1CCNB2CDK1 | |
| SCHEMBL7048414 | 0.79 | CES1 (0.46) | CES1TGM2ALDH1A1 | |
| SCHEMBL7048416 | 0.79 | CES1 (0.46) | CES1TGM2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0706396-B1 | 1,2,3,4-TETRAHYDROQUINOLINE-2,3,4-TRIONE-3 OR 4-OXIMES AND USE | OREGON STATE (US) | 2003-05-02 | — | — | EP | disclosed |
| US-5652368-A | NERVOUS SYSTEM DISORDERS, ALZHEIMER'S DISEASE | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1997-07-29 | — | — | US | disclosed |
| US-5475007-A | Preventing convulsions | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1995-12-12 | — | — | US | disclosed |