Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 8/20 | 0.72 |
| ▸ | ADRA1A | P35348 | 6/20 | 0.72 |
| ▸ | ADRA1D | P25100 | 5/20 | 0.72 |
| ▸ | ADRA1B | P35368 | 5/20 | 0.72 |
| ▸ | LMNA | P02545 | 2/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.60 |
| ▸ | HTR2A | P28223 | 6/20 | 0.53 |
| ▸ | HTR2C | P28335 | 6/20 | 0.53 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.53 |
| ▸ | DRD3 | P35462 | 3/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.51 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7051331 | 0.91 | HTR1A (0.81) | HTR1AADRA1AADRA1DADRA1BLMNA | |
| SCHEMBL8875520 | 0.91 | HTR1A (0.84) | HTR1AADRA1AADRA1DADRA1BLMNA | |
| SCHEMBL8876351 | 0.89 | HTR1A (0.81) | HTR1AADRA1AADRA1DADRA1BLMNA | |
| SCHEMBL8876429 | 0.89 | HTR1A (0.71) | HTR1AADRA1AADRA1DADRA1BLMNA | |
| SCHEMBL8875778 | 0.88 | HTR1A (0.73) | HTR1AADRA1AADRA1DADRA1BLMNA | |
| SCHEMBL7050780 | 0.87 | HTR1A (0.55) | HTR1AADRA1AADRA1DADRA1BSMN1; SMN2 | |
| SCHEMBL7054044 | 0.87 | HTR1A (0.69) | HTR1AADRA1AADRA1DADRA1BLMNA | |
| SCHEMBL8875767 | 0.87 | HTR1A (0.77) | HTR1AADRA1AADRA1DADRA1BLMNA | |
| SCHEMBL7052255 | 0.86 | HTR1A (0.68) | HTR1AADRA1AADRA1DADRA1BLMNA | |
| Hydrochloric Acid SCHEMBL7054302 | 0.86 | HTR1A (0.67) | HTR1AADRA1AADRA1DADRA1BLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5605896-A | Bicyclic heterocyclic derivatives having α1 adrenergic and 5HT1A activities | RECORDATI S.A., CHEMICAL AND PHARMACEUTICAL COMPANY (CH) | 1997-02-25 | — | — | US | claimed |
| EP-1222183-B1 | BENZOPYRAN DERIVATIVES | RECORDATI CHEM PHARM (IT) | 2003-04-23 | — | — | EP | disclosed |
| US-6403594-B1 | UROGENTIAL INFECTIONS, ETC | RECORDATI, S.A. CHEMICAL AND PHARMACEUTICAL COMPANY (CH) | 2002-06-11 | — | — | US | disclosed |