Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 1/20 | 0.74 |
| ▸ | THRB | P10828 | 16/20 | 0.48 |
| ▸ | THRA | P10827 | 15/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7687151 | 0.91 | NR3C1 (0.62) | NR3C1THRBTHRAPOLBMAPT | |
| SCHEMBL7054870 | 0.91 | NR3C1 (0.81) | NR3C1THRBTHRA | |
| SCHEMBL7052325 | 0.91 | NR3C1 (0.84) | NR3C1THRBTHRA | |
| SCHEMBL7052047 | 0.90 | NR3C1 (0.74) | NR3C1THRBTHRAMAPT | |
| SCHEMBL7054052 | 0.90 | NR3C1 (0.74) | NR3C1THRBTHRA | |
| SCHEMBL7054486 | 0.90 | NR3C1 (0.82) | NR3C1THRBTHRA | |
| SCHEMBL7053492 | 0.89 | NR3C1 (0.58) | NR3C1THRBTHRAPOLBMAPT | |
| SCHEMBL7256429 | 0.87 | NR3C1 (0.75) | NR3C1THRBTHRA | |
| SCHEMBL7253471 | 0.86 | NR3C1 (0.82) | NR3C1THRBTHRA | |
| SCHEMBL7054470 | 0.86 | NR3C1 (0.84) | NR3C1THRBTHRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1102739-B1 | GLUCOCORTICOID AND THYROID HORMONE RECEPTOR LIGANDS FOR THE TREATMENT OF METABOLIC DISORDERS | KAROBIO AB (SE) | 2003-04-23 | — | — | EP | claimed |
| US-6492424-B1 | Glucocorticoid and thyroid hormone receptor ligands for the treatment of metabolic disorders | KARO BIO AB (SE) | 2002-12-10 | — | — | US | claimed |
| US-6492424-B1 | Glucocorticoid and thyroid hormone receptor ligands for the treatment of metabolic disorders | KARO BIO AB (SE) | 2002-12-10 | — | — | US | disclosed |