Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 1/20 | 0.62 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 13/20 | 0.39 |
| ▸ | THRA | P10827 | 12/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.37 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.36 |
| ▸ | RORC | P51449 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7051707 | 0.91 | NR3C1 (0.74) | NR3C1POLBTHRBTHRAMAPT | |
| SCHEMBL7053405 | 0.91 | NR3C1 (0.68) | NR3C1THRBTHRAMAPTLPAR1 | |
| SCHEMBL7050206 | 0.91 | NR3C1 (0.62) | NR3C1THRBTHRAMAPT | |
| SCHEMBL7052767 | 0.91 | NR3C1 (0.62) | NR3C1THRBTHRAMAPT | |
| SCHEMBL7053515 | 0.90 | NR3C1 (0.72) | NR3C1THRBTHRAMAPTRORC | |
| SCHEMBL7688423 | 0.90 | NR3C1 (0.69) | NR3C1THRBTHRALPAR1RORC | |
| SCHEMBL7051600 | 0.89 | NR3C1 (0.53) | NR3C1THRBTHRAMAPTLPAR1 | |
| SCHEMBL7053492 | 0.88 | NR3C1 (0.58) | NR3C1POLBTHRBTHRAMAPT | |
| SCHEMBL7249363 | 0.87 | NR3C1 (0.63) | NR3C1THRBTHRA | |
| SCHEMBL7256183 | 0.87 | NR3C1 (0.69) | NR3C1THRBTHRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6492424-B1 | Glucocorticoid and thyroid hormone receptor ligands for the treatment of metabolic disorders | KARO BIO AB (SE) | 2002-12-10 | — | — | US | disclosed |