Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 5/20 | 0.65 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.65 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.65 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.65 |
| ▸ | CNR2 | P34972 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7054222 | 0.94 | PDE4A (0.58) | PDE4APDE4BPDE4CPDE4DCNR2 | |
| SCHEMBL7055640 | 0.91 | LMNA (0.58) | PDE4APDE4BPDE4CPDE4DCNR2 | |
| SCHEMBL7058521 | 0.89 | CNR2 (0.54) | PDE4APDE4BPDE4CPDE4DCNR2 | |
| SCHEMBL7051878 | 0.89 | PDE4A (0.53) | PDE4APDE4BPDE4CPDE4DCNR2 | |
| SCHEMBL7057001 | 0.88 | PDE4A (0.54) | PDE4APDE4BPDE4CPDE4DCNR2 | |
| SCHEMBL7056215 | 0.86 | PDE4A (0.49) | PDE4APDE4BPDE4CPDE4DCNR2 | |
| SCHEMBL7057844 | 0.85 | PDE4A (0.68) | PDE4APDE4BPDE4CPDE4DCNR2 | |
| SCHEMBL7050618 | 0.85 | PDE4A (0.49) | PDE4APDE4BPDE4CPDE4DCNR2 | |
| SCHEMBL7050610 | 0.85 | TP53 (0.56) | PDE4APDE4BPDE4CPDE4DCNR2 | |
| SCHEMBL7055521 | 0.82 | PDE4A (0.53) | PDE4APDE4BPDE4CPDE4DMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0841929-B1 | QUINOLONES AND THEIR THERAPEUTIC USE | DARWIN DISCOVERY LTD (GB) | 2003-05-07 | — | — | EP | claimed |