Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 7/20 | 0.53 |
| ▸ | PDE4B | Q07343 | 7/20 | 0.53 |
| ▸ | PDE4C | Q08493 | 7/20 | 0.53 |
| ▸ | PDE4D | Q08499 | 7/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.47 |
| ▸ | CNR2 | P34972 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.43 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.43 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.42 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7056153 | 0.92 | ALDH1A1 (0.56) | ALDH1A1KDM4EMAPK1PDE10AMEN1 | |
| SCHEMBL7051834 | 0.89 | PDE4A (0.65) | PDE4APDE4BPDE4CPDE4DALDH1A1 | |
| SCHEMBL7057844 | 0.84 | PDE4A (0.68) | PDE4APDE4BPDE4CPDE4DALDH1A1 | |
| SCHEMBL7054222 | 0.83 | PDE4A (0.58) | PDE4APDE4BPDE4CPDE4DALDH1A1 | |
| SCHEMBL7057001 | 0.83 | PDE4A (0.54) | PDE4APDE4BPDE4CPDE4DALDH1A1 | |
| SCHEMBL7055521 | 0.83 | PDE4A (0.53) | PDE4APDE4BPDE4CPDE4DALDH1A1 | |
| SCHEMBL7058521 | 0.83 | CNR2 (0.54) | PDE4APDE4BPDE4CPDE4DALDH1A1 | |
| SCHEMBL7050618 | 0.83 | PDE4A (0.49) | PDE4APDE4BPDE4CPDE4DALDH1A1 | |
| SCHEMBL7055640 | 0.81 | LMNA (0.58) | PDE4APDE4BPDE4CPDE4DALDH1A1 | |
| SCHEMBL7051841 | 0.81 | PDE4A (0.80) | PDE4APDE4BPDE4CPDE4DALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0841929-B1 | QUINOLONES AND THEIR THERAPEUTIC USE | DARWIN DISCOVERY LTD (GB) | 2003-05-07 | — | — | EP | claimed |