Uracil

Uracil

SCHEMBL7051932

Cn1c(N)cc(=O)n(C)c1=O.O=c1cc[nH]c(=O)[nH]1

nearest known ligand 0.52

Full drug profile on Sugi Atlas →

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
CRBN Q96SW2 2/20 0.52
HPGD P15428 2/20 0.39
CYP3A4 P08684 1/20 0.39
ALDH1A1 P00352 1/20 0.39
MMP2 P08253 1/20 0.34
TP53 P04637 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
BACE1 P56817 2/20 0.33
MEN1 O00255 1/20 0.33
KMT2A Q03164 1/20 0.33
POLB P06746 1/20 0.32
PABPC1 P11940 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1031716 0.78 ALDH1A1 (0.41) HPGDCYP3A4ALDH1A1SMN1; SMN2MEN1
SCHEMBL23857 0.78 ALDH1A1 (0.55) HPGDCYP3A4ALDH1A1MEN1KMT2A
SCHEMBL28143898 0.76 ALDH1A1 (0.53) HPGDCYP3A4ALDH1A1MEN1KMT2A
Uracil SCHEMBL28128133 0.75 CRBN (0.55) CRBNMMP2TP53
Uracil SCHEMBL8235 0.72
Uracil SCHEMBL5089507 0.72
Uracil SCHEMBL3798527 0.72 CRBN (1.00) CRBNALDH1A1MMP2TP53SMN1; SMN2
Uracil SCHEMBL11607890 0.72
Urea SCHEMBL28689542 0.71 ALDH1A1 (0.49) HPGDCYP3A4ALDH1A1SMN1; SMN2MEN1
Uracil SCHEMBL28867999 0.70 CRBN (0.85) CRBNALDH1A1MMP2TP53SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2235099-B1 STABILIZER COMPOSITION FOR HALOGENATED POLYMERS CHEMSON POLYMER ADDITIVE AG (AT) 2013-05-22 EP claimed
EP-2235099-B1 STABILIZER COMPOSITION FOR HALOGENATED POLYMERS CHEMSON POLYMER ADDITIVE AG (AT) 2013-05-22 EP disclosed
EP-1303564-A2 STABILISER SYSTEM COMPRISING HYDROXYACIDS Akzo Nobel N.V. (NL) 2003-04-23 EP disclosed
US-20020032259-A1 Stabliser system comprising hydroxyacids AKZO NOBEL N.V. (NL) 2002-03-14 US disclosed
WO-2002006389-A2 STABILISER SYSTEM COMPRISING HYDROXYACIDS AKZO NOBEL N.V. (NL) 2002-01-24 WO disclosed