Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 12/20 | 0.61 |
| ▸ | PDE4B | Q07343 | 12/20 | 0.61 |
| ▸ | PDE4C | Q08493 | 12/20 | 0.61 |
| ▸ | PDE4D | Q08499 | 12/20 | 0.61 |
| ▸ | SLC22A12 | Q96S37 | 7/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11752418 | 0.87 | PDE4A (0.60) | PDE4APDE4BPDE4CPDE4DSLC22A12 | |
| SCHEMBL7053201 | 0.87 | PDE4A (0.60) | PDE4APDE4BPDE4CPDE4DSLC22A12 | |
| SCHEMBL7055266 | 0.85 | PDE4D (0.64) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL1287513 | 0.81 | SLC22A12 (0.67) | PDE4APDE4BPDE4CPDE4DSLC22A12 | |
| SCHEMBL7050573 | 0.80 | PDE4A (0.61) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL7055897 | 0.78 | PDE4A (0.53) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL2260596 | 0.77 | PDE4A (0.49) | PDE4APDE4BPDE4CPDE4DSLC22A12 | |
| SCHEMBL7051464 | 0.76 | PDE4D (0.76) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6605574 | 0.75 | PDE4A (0.47) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL18325768 | 0.75 | SLC22A12 (0.48) | PDE4APDE4BPDE4CPDE4DSLC22A12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0901482-B1 | BENZOFURAN CARBOXAMIDES AND THEIR THERAPEUTIC USE | DARWIN DISCOVERY LTD (GB) | 2003-05-02 | — | — | EP | disclosed |
| US-5925636-A | Benzofuran carboxamides and their therapeutic use | DARWIN DISCOVERY LIMITED (GB) | 1999-07-20 | — | — | US | disclosed |
| EP-0901482-A1 | BENZOFURAN CARBOXAMIDES AND THEIR THERAPEUTIC USE | Darwin Discovery Limited (GB) | 1999-03-17 | — | — | EP | disclosed |
| EP-0873331-A1 | BENZOFURAN CARBOXAMIDES AND SULPHONAMIDES | Darwin Discovery Limited (GB) | 1998-10-28 | — | — | EP | disclosed |
| US-5773467-A | Benzofuran sulphonanmides | CHIROSCIENCE, LTD. (GB) | 1998-06-30 | — | — | US | disclosed |
| WO-1997044337-A1 | BENZOFURAN CARBOXAMIDES AND THEIR THERAPEUTIC USE | DARWIN DISCOVERY LIMITED (GB) | 1997-11-27 | — | — | WO | disclosed |
| WO-1997020833-A1 | BENZOFURAN CARBOXAMIDES AND SULPHONAMIDES | DARWIN DISCOVERY LIMITED (GB) | 1997-06-12 | — | — | WO | disclosed |