Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 15/20 | 0.61 |
| ▸ | PDE4B | Q07343 | 15/20 | 0.61 |
| ▸ | PDE4C | Q08493 | 15/20 | 0.61 |
| ▸ | PDE4D | Q08499 | 15/20 | 0.61 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | RECQL | P46063 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7055897 | 0.89 | PDE4A (0.53) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL7056726 | 0.87 | PDE4A (0.62) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL309047 | 0.82 | PDE4A (0.60) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL7054715 | 0.82 | PDE4B (0.68) | PDE4APDE4BPDE4CPDE4DALDH1A1 | |
| Hydrochloric Acid SCHEMBL7053217 | 0.81 | PDE4B (0.67) | PDE4APDE4BPDE4CPDE4DALDH1A1 | |
| SCHEMBL7049311 | 0.81 | PDE4A (0.56) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL7052318 | 0.80 | PDE4A (0.61) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL3610073 | 0.79 | LMNA (0.57) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL7407273 | 0.77 | LMNA (0.52) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL22442113 | 0.77 | PDE4A (0.57) | PDE4APDE4BPDE4CPDE4DLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0901482-B1 | BENZOFURAN CARBOXAMIDES AND THEIR THERAPEUTIC USE | DARWIN DISCOVERY LTD (GB) | 2003-05-02 | — | — | EP | disclosed |
| US-5972936-A | Benzofuran carboxamides and their therapeutic use | DARWIN DISCOVER LIMITED (GB) | 1999-10-26 | — | — | US | disclosed |
| US-5925636-A | Benzofuran carboxamides and their therapeutic use | DARWIN DISCOVERY LIMITED (GB) | 1999-07-20 | — | — | US | disclosed |
| EP-0901482-A1 | BENZOFURAN CARBOXAMIDES AND THEIR THERAPEUTIC USE | Darwin Discovery Limited (GB) | 1999-03-17 | — | — | EP | disclosed |
| US-5773467-A | Benzofuran sulphonanmides | CHIROSCIENCE, LTD. (GB) | 1998-06-30 | — | — | US | disclosed |
| WO-1997044337-A1 | BENZOFURAN CARBOXAMIDES AND THEIR THERAPEUTIC USE | DARWIN DISCOVERY LIMITED (GB) | 1997-11-27 | — | — | WO | disclosed |