Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 6/20 | 0.60 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.60 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.60 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.60 |
| ▸ | SLC22A12 | Q96S37 | 7/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA3 | P07451 | 1/20 | 0.44 |
| ▸ | CA4 | P22748 | 1/20 | 0.44 |
| ▸ | CA6 | P23280 | 1/20 | 0.44 |
| ▸ | CA5A | P35218 | 1/20 | 0.44 |
| ▸ | CA7 | P43166 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.44 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11752418 | 0.89 | PDE4A (0.60) | PDE4APDE4BPDE4CPDE4DSLC22A12 | |
| SCHEMBL6605574 | 0.87 | PDE4A (0.47) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL7052318 | 0.87 | PDE4A (0.61) | PDE4APDE4BPDE4CPDE4DSLC22A12 | |
| SCHEMBL3924757 | 0.87 | KDM4E (0.49) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL7050225 | 0.85 | PDE4D (0.62) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL3931673 | 0.84 | PDE4A (0.45) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL3922215 | 0.83 | PPARG (0.44) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL1287513 | 0.82 | SLC22A12 (0.67) | PDE4APDE4BPDE4CPDE4DSLC22A12 | |
| SCHEMBL7365432 | 0.81 | PDE4D (0.43) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL73952 | 0.81 | ALDH1A1 (0.47) | PDE4APDE4BPDE4CPDE4DKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0901482-B1 | BENZOFURAN CARBOXAMIDES AND THEIR THERAPEUTIC USE | DARWIN DISCOVERY LTD (GB) | 2003-05-02 | — | — | EP | disclosed |
| US-5925636-A | Benzofuran carboxamides and their therapeutic use | DARWIN DISCOVERY LIMITED (GB) | 1999-07-20 | — | — | US | disclosed |
| EP-0901482-A1 | BENZOFURAN CARBOXAMIDES AND THEIR THERAPEUTIC USE | Darwin Discovery Limited (GB) | 1999-03-17 | — | — | EP | disclosed |
| US-5773467-A | Benzofuran sulphonanmides | CHIROSCIENCE, LTD. (GB) | 1998-06-30 | — | — | US | disclosed |
| WO-1997044337-A1 | BENZOFURAN CARBOXAMIDES AND THEIR THERAPEUTIC USE | DARWIN DISCOVERY LIMITED (GB) | 1997-11-27 | — | — | WO | disclosed |