Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 7/20 | 0.78 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.60 |
| ▸ | MAPT | P10636 | 6/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.59 |
| ▸ | LMNA | P02545 | 3/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | PTPRF | P10586 | 1/20 | 0.56 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7059470 | 0.88 | IKBKB (0.69) | IKBKBMAPTKDM4ELMNAALDH1A1 | |
| SCHEMBL7057270 | 0.86 | MAPT (0.76) | IKBKBNPSR1MAPTKDM4ELMNA | |
| SCHEMBL7052667 | 0.85 | IKBKB (0.78) | IKBKBNPSR1MAPTKDM4ELMNA | |
| SCHEMBL12768509 | 0.75 | PTPN1 (0.69) | IKBKBMAPTLMNAALDH1A1PTPRF | |
| SCHEMBL7051768 | 0.75 | IKBKB (0.64) | IKBKBMAPTPTPN1HPGD | |
| SCHEMBL5368759 | 0.74 | MAPT (1.00) | IKBKBNPSR1MAPTKDM4ELMNA | |
| SCHEMBL17226314 | 0.74 | PTPN1 (0.68) | IKBKBMAPTKDM4ELMNAALDH1A1 | |
| SCHEMBL7057171 | 0.74 | PTPN1 (0.72) | IKBKBMAPTALDH1A1PTPRFPTPN1 | |
| SCHEMBL7057485 | 0.74 | IKBKB (0.63) | IKBKBMAPTKDM4ELMNAALDH1A1 | |
| SCHEMBL7050948 | 0.73 | IKBKB (0.80) | IKBKBMAPTKDM4ELMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003028731-A1 | CHK1 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-04-10 | — | — | WO | disclosed |