Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES1 | P23141 | 2/20 | 0.38 |
| ▸ | UCHL3 | P15374 | 3/20 | 0.32 |
| ▸ | UCHL1 | P09936 | 3/20 | 0.32 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.31 |
| ▸ | CDK1 | P06493 | 1/20 | 0.31 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.31 |
| ▸ | GSK3A | P49840 | 1/20 | 0.31 |
| ▸ | GSK3B | P49841 | 1/20 | 0.31 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.31 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.31 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.31 |
| ▸ | JUN | P05412 | 2/20 | 0.31 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.31 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.31 |
| ▸ | RELA | Q04206 | 2/20 | 0.31 |
| ▸ | GABRP | O00591 | 1/20 | 0.31 |
| ▸ | GABRD | O14764 | 1/20 | 0.31 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.31 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.31 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7050452 | 0.92 | CES1 (0.38) | CES1UCHL3UCHL1CCNB2CDK1 | |
| SCHEMBL7056837 | 0.87 | ALDH1A1 (0.30) | ALDH1A1MAPTHPGDALOX15HSD17B10 | |
| SCHEMBL7047393 | 0.86 | CES1 (0.54) | CES1UCHL3UCHL1CCNB2CDK1 | |
| SCHEMBL7049367 | 0.86 | NOTUM (0.32) | CES1CCNB2CDK1CCNB1GSK3A | |
| SCHEMBL7054180 | 0.83 | HPGD (0.37) | CES1ALDH1A1MAPTMAPK1HPGD | |
| SCHEMBL7048278 | 0.81 | GALR3 (0.32) | ALDH1A1MAPTHPGDALOX15HSD17B10 | |
| SCHEMBL8871331 | 0.81 | CES1 (0.45) | CES1JUNNFKB1NFKB2RELA | |
| SCHEMBL8871333 | 0.81 | CES1 (0.45) | CES1JUNNFKB1NFKB2RELA | |
| SCHEMBL7053378 | 0.80 | CES1 (0.39) | CES1UCHL3UCHL1CCNB2CDK1 | |
| SCHEMBL7051913 | 0.80 | GALR3 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0706396-B1 | 1,2,3,4-TETRAHYDROQUINOLINE-2,3,4-TRIONE-3 OR 4-OXIMES AND USE | OREGON STATE (US) | 2003-05-02 | — | — | EP | disclosed |
| US-5652368-A | NERVOUS SYSTEM DISORDERS, ALZHEIMER'S DISEASE | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1997-07-29 | — | — | US | disclosed |
| US-5475007-A | Preventing convulsions | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1995-12-12 | — | — | US | disclosed |