Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 2/20 | 0.83 |
| ▸ | THRA | P10827 | 17/20 | 0.48 |
| ▸ | THRB | P10828 | 17/20 | 0.48 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | PGR | P06401 | 1/20 | 0.39 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.39 |
| ▸ | AR | P10275 | 1/20 | 0.39 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.37 |
| ▸ | WNT3A | P56704 | 1/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7050568 | 0.92 | NR3C1 (0.76) | NR3C1THRATHRBCTNNB1WNT3A | |
| SCHEMBL5632584 | 0.91 | NR3C1 (1.00) | NR3C1THRATHRB | |
| SCHEMBL7050844 | 0.86 | NR3C1 (0.85) | NR3C1THRATHRBCTNNB1WNT3A | |
| SCHEMBL5630623 | 0.86 | NR3C1 (0.85) | NR3C1THRATHRBCTNNB1WNT3A | |
| SCHEMBL7684969 | 0.85 | NR3C1 (0.88) | NR3C1THRATHRBCTNNB1WNT3A | |
| SCHEMBL7052439 | 0.84 | NR3C1 (0.75) | NR3C1THRATHRBCTNNB1WNT3A | |
| SCHEMBL7055432 | 0.83 | NR3C1 (0.73) | NR3C1CTNNB1WNT3A | |
| SCHEMBL5631912 | 0.83 | NR3C1 (0.85) | NR3C1THRATHRB | |
| SCHEMBL7250252 | 0.83 | NR3C1 (0.58) | NR3C1THRATHRBESR1PGR | |
| SCHEMBL7054470 | 0.83 | NR3C1 (0.84) | NR3C1THRATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1102739-B1 | GLUCOCORTICOID AND THYROID HORMONE RECEPTOR LIGANDS FOR THE TREATMENT OF METABOLIC DISORDERS | KAROBIO AB (SE) | 2003-04-23 | — | — | EP | claimed |
| US-6492424-B1 | Glucocorticoid and thyroid hormone receptor ligands for the treatment of metabolic disorders | KARO BIO AB (SE) | 2002-12-10 | — | — | US | claimed |
| US-6492424-B1 | Glucocorticoid and thyroid hormone receptor ligands for the treatment of metabolic disorders | KARO BIO AB (SE) | 2002-12-10 | — | — | US | disclosed |