Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 1/20 | 0.75 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.37 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.37 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.37 |
| ▸ | THPO | P40225 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7050566 | 0.92 | NR3C1 (0.71) | NR3C1PTGS1PTGS2KDM4EALDH1A1 | |
| SCHEMBL5632584 | 0.86 | NR3C1 (1.00) | NR3C1HSD17B10THRATHRB | |
| SCHEMBL7055432 | 0.85 | NR3C1 (0.73) | NR3C1HPGDKDM4EALDH1A1CYP3A4 | |
| SCHEMBL7053031 | 0.84 | NR3C1 (0.83) | NR3C1CTNNB1WNT3ATHRATHRB | |
| SCHEMBL5630623 | 0.83 | NR3C1 (0.85) | NR3C1KDM4EALDH1A1CYP3A4CYP1A2 | |
| SCHEMBL7050844 | 0.83 | NR3C1 (0.85) | NR3C1KDM4EALDH1A1POLBLPAR1 | |
| SCHEMBL7250248 | 0.83 | NR3C1 (0.52) | NR3C1PTGS1LPAR1AKR1C3AKR1C2 | |
| SCHEMBL7050568 | 0.82 | NR3C1 (0.76) | NR3C1MAPTKDM4EALDH1A1CYP3A4 | |
| SCHEMBL7052846 | 0.81 | NR3C1 (0.67) | NR3C1MAPTSMN1; SMN2HPGDKDM4E | |
| SCHEMBL7684969 | 0.81 | NR3C1 (0.88) | NR3C1POLBNPC1RAB9ACTNNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1102739-B1 | GLUCOCORTICOID AND THYROID HORMONE RECEPTOR LIGANDS FOR THE TREATMENT OF METABOLIC DISORDERS | KAROBIO AB (SE) | 2003-04-23 | — | — | EP | claimed |
| US-6492424-B1 | Glucocorticoid and thyroid hormone receptor ligands for the treatment of metabolic disorders | KARO BIO AB (SE) | 2002-12-10 | — | — | US | claimed |
| US-6492424-B1 | Glucocorticoid and thyroid hormone receptor ligands for the treatment of metabolic disorders | KARO BIO AB (SE) | 2002-12-10 | — | — | US | disclosed |