Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 15/20 | 0.47 |
| ▸ | MTNR1B | P49286 | 13/20 | 0.47 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | RORC | P51449 | 3/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.35 |
| ▸ | NQO2 | P16083 | 1/20 | 0.35 |
| ▸ | ACACB | O00763 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27493167 | 0.85 | MTNR1A (0.45) | MTNR1AMTNR1BHTR2CRORCAKR1C3 | |
| SCHEMBL7057889 | 0.75 | MTNR1A (0.42) | MTNR1AMTNR1BHTR2CAKR1C3 | |
| SCHEMBL8711498 | 0.71 | MEN1 (0.41) | MTNR1AMTNR1BAKR1C3NQO2 | |
| SCHEMBL7055786 | 0.68 | MTNR1A (0.75) | MTNR1AMTNR1BHTR2CNQO2 | |
| SCHEMBL7053336 | 0.67 | MTNR1A (0.34) | MTNR1AMTNR1BRORC | |
| SCHEMBL10566139 | 0.66 | MTNR1A (0.56) | MTNR1AMTNR1BHTR2CAKR1C3NQO2 | |
| SCHEMBL7050429 | 0.66 | MTNR1A (0.53) | MTNR1AMTNR1BHTR2CAKR1C3 | |
| SCHEMBL7060002 | 0.66 | MTNR1A (0.32) | MTNR1AMTNR1BRORC | |
| SCHEMBL7055145 | 0.65 | ACACB (0.35) | MTNR1AMTNR1BHTR2CACACB | |
| SCHEMBL7060005 | 0.62 | MTNR1A (0.35) | MTNR1AMTNR1BRORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0656209-B1 | Melatonin derivatives for use in treating desynchronization disorders | LILLY CO ELI (US) | 2003-05-07 | — | — | EP | disclosed |
| CN-1100533-C | Melatonin derivatives for use in terating desynchronization disorders | LILLY CO ELI (US) | 2003-02-05 | — | — | CN | disclosed |
| CN-1092958-C | Melatonin derivatives for use in treating sleep disorders | LILLY CO ELI (US) | 2002-10-23 | — | — | CN | disclosed |
| EP-0655243-B1 | Melatonin derivatives for use in treating sleep disorders | LILLY CO ELI (US) | 2002-08-21 | — | — | EP | disclosed |
| US-6180657-B1 | SLEEP DISORDERS | ELI LILLY AND COMPANY | 2001-01-30 | — | — | US | disclosed |
| US-5770610-A | ADMINISTERING R-(+)-N-(2-METHYL-2-(5-METHOXY-6-CHLOROINDOL-3-YL)ETHYL) ACETAMIDE | ELI LILLY AND COMPANY (US) | 1998-06-23 | — | — | US | disclosed |
| US-5654325-A | Melatonin derivatives for use in treating sleep disorders | ELI LILLY AND COMPANY (US) | 1997-08-05 | — | — | US | disclosed |
| EP-0748627-A2 | Melatonin agonists for use in the treatment of benign prostatic hyperplasia | ELI LILLY AND COMPANY (US) | 1996-12-18 | — | — | EP | disclosed |
| CN-1107701-A | Melatonin derivatives for use in treating sleep disorders | LILLY CO ELI (US) | 1995-09-06 | — | — | CN | disclosed |
| CN-1107700-A | Melatonin derivatives for use in terating desynchronization disorders | LILLY CO ELI (US) | 1995-09-06 | — | — | CN | disclosed |
| EP-0656209-A2 | Melatonin derivatives for use in treating desynchronization disorders | ELI LILLY AND COMPANY (US) | 1995-06-07 | — | — | EP | disclosed |
| EP-0655243-A2 | Melatonin derivatives for use in treating sleep disorders | ELI LILLY AND COMPANY (US) | 1995-05-31 | — | — | EP | disclosed |
| US-4997845-A | β-alkylmelatonins as ovulation inhibitors | ELI LILLY AND COMPANY (US) | 1991-03-05 | — | — | US | disclosed |