Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | PTPN1 | P18031 | 4/20 | 0.51 |
| ▸ | MMP2 | P08253 | 2/20 | 0.48 |
| ▸ | MMP9 | P14780 | 2/20 | 0.48 |
| ▸ | BMP1 | P13497 | 1/20 | 0.45 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MMP3 | P08254 | 1/20 | 0.44 |
| ▸ | F2 | P00734 | 3/20 | 0.43 |
| ▸ | TMPRSS6 | Q8IU80 | 3/20 | 0.43 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | SGMS1 | Q86VZ5 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7155948 | 0.94 | POLB (0.51) | POLBPTPN1MMP2MMP9BMP1 | |
| SCHEMBL4650907 | 0.94 | POLB (0.51) | POLBPTPN1MMP2MMP9BMP1 | |
| SCHEMBL4651310 | 0.94 | PTPN1 (0.57) | POLBPTPN1MMP2MMP9BMP1 | |
| SCHEMBL4651215 | 0.86 | PTPN1 (0.60) | POLBPTPN1MMP2MMP9ALDH1A1 | |
| SCHEMBL4650871 | 0.84 | PTPN1 (0.62) | PTPN1MMP2MMP9BMP1ALDH1A1 | |
| SCHEMBL4650968 | 0.84 | PTPN1 (0.62) | PTPN1MMP2MMP9BMP1HSD17B10 | |
| SCHEMBL7053662 | 0.82 | ALDH1A1 (0.47) | POLBMMP2MMP9ALDH1A1SGMS1 | |
| SCHEMBL4650321 | 0.79 | ALDH1A1 (0.49) | PTPN1ALDH1A1HPGDHSD17B10 | |
| SCHEMBL4651374 | 0.79 | PTPN1 (0.56) | PTPN1ALDH1A1 | |
| SCHEMBL4650268 | 0.78 | PTPN1 (0.58) | PTPN1MMP2MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1301474-A2 | TYROSINE DERIVATIVES AS PHOSPHATASE INHIBITORS | Array Biopharma Inc. (US) | 2003-04-16 | — | — | EP | disclosed |
| WO-2002004412-A2 | TYROSINE DERIVATIVES AS PHOSPHATASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2002-01-17 | — | — | WO | disclosed |