Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 1/20 | 0.75 |
| ▸ | THRB | P10828 | 16/20 | 0.43 |
| ▸ | THRA | P10827 | 14/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7049890 | 0.93 | NR3C1 (0.64) | NR3C1THRBTHRAMAPK14 | |
| SCHEMBL7688523 | 0.92 | NR3C1 (0.79) | NR3C1THRBTHRA | |
| SCHEMBL7054321 | 0.92 | NR3C1 (0.78) | NR3C1THRBTHRA | |
| SCHEMBL7050851 | 0.90 | NR3C1 (0.75) | NR3C1THRBTHRA | |
| SCHEMBL7048666 | 0.90 | NR3C1 (0.75) | NR3C1THRBTHRA | |
| SCHEMBL7054470 | 0.87 | NR3C1 (0.84) | NR3C1THRBTHRA | |
| SCHEMBL7052325 | 0.87 | NR3C1 (0.84) | NR3C1THRBTHRA | |
| SCHEMBL7054567 | 0.86 | NR3C1 (0.83) | NR3C1THRBTHRA | |
| SCHEMBL5632584 | 0.86 | NR3C1 (1.00) | NR3C1THRBTHRAALOX15TSHR | |
| SCHEMBL7047606 | 0.85 | NR3C1 (0.82) | NR3C1THRBTHRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1102739-B1 | GLUCOCORTICOID AND THYROID HORMONE RECEPTOR LIGANDS FOR THE TREATMENT OF METABOLIC DISORDERS | KAROBIO AB (SE) | 2003-04-23 | — | — | EP | claimed |
| US-6492424-B1 | Glucocorticoid and thyroid hormone receptor ligands for the treatment of metabolic disorders | KARO BIO AB (SE) | 2002-12-10 | — | — | US | claimed |
| EP-1102739-B1 | GLUCOCORTICOID AND THYROID HORMONE RECEPTOR LIGANDS FOR THE TREATMENT OF METABOLIC DISORDERS | KAROBIO AB (SE) | 2003-04-23 | — | — | EP | disclosed |
| US-6492424-B1 | Glucocorticoid and thyroid hormone receptor ligands for the treatment of metabolic disorders | KARO BIO AB (SE) | 2002-12-10 | — | — | US | disclosed |