Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 1/20 | 0.79 |
| ▸ | THRB | P10828 | 17/20 | 0.45 |
| ▸ | THRA | P10827 | 15/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7050851 | 0.94 | NR3C1 (0.75) | NR3C1THRBTHRA | |
| SCHEMBL7048666 | 0.92 | NR3C1 (0.75) | NR3C1THRBTHRA | |
| SCHEMBL7054210 | 0.92 | NR3C1 (0.75) | NR3C1THRBTHRA | |
| SCHEMBL7054321 | 0.92 | NR3C1 (0.78) | NR3C1THRBTHRA | |
| SCHEMBL7052325 | 0.91 | NR3C1 (0.84) | NR3C1THRBTHRACYP1A2CYP2D6 | |
| SCHEMBL7054470 | 0.89 | NR3C1 (0.84) | NR3C1THRBTHRACYP1A2CYP2C19 | |
| SCHEMBL5632584 | 0.88 | NR3C1 (1.00) | NR3C1THRBTHRA | |
| SCHEMBL7054567 | 0.88 | NR3C1 (0.83) | NR3C1THRBTHRA | |
| SCHEMBL7047606 | 0.88 | NR3C1 (0.82) | NR3C1THRBTHRA | |
| SCHEMBL7050835 | 0.88 | NR3C1 (0.82) | NR3C1THRBTHRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6492424-B1 | Glucocorticoid and thyroid hormone receptor ligands for the treatment of metabolic disorders | KARO BIO AB (SE) | 2002-12-10 | — | — | US | claimed |