Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 12/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 12/20 | 0.47 |
| ▸ | PDE4C | Q08493 | 12/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 12/20 | 0.47 |
| ▸ | ECE1 | P42892 | 1/20 | 0.40 |
| ▸ | AHR | P35869 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA3 | P07451 | 1/20 | 0.37 |
| ▸ | CA4 | P22748 | 1/20 | 0.37 |
| ▸ | CA6 | P23280 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7053222 | 0.85 | F2RL3 (0.42) | PDE4APDE4BPDE4CPDE4DECE1 | |
| SCHEMBL7051138 | 0.80 | PDE4B (0.66) | PDE4APDE4BPDE4CPDE4DSMN1; SMN2 | |
| SCHEMBL7050590 | 0.80 | RAB9A (0.43) | PDE4APDE4BPDE4CPDE4DSMN1; SMN2 | |
| SCHEMBL7056726 | 0.79 | PDE4A (0.62) | PDE4APDE4BPDE4CPDE4DSMN1; SMN2 | |
| SCHEMBL6839328 | 0.78 | SMN1; SMN2 (0.62) | PDE4APDE4BPDE4CPDE4DSMN1; SMN2 | |
| SCHEMBL7053276 | 0.78 | RAB9A (0.62) | SMN1; SMN2RAB9ANPC1MEN1KMT2A | |
| SCHEMBL7051399 | 0.76 | PDE4A (0.55) | PDE4APDE4BPDE4CPDE4DSMN1; SMN2 | |
| SCHEMBL6839386 | 0.72 | PDE4A (0.48) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7053236 | 0.72 | PDE4A (0.50) | PDE4APDE4BPDE4CPDE4DSMN1; SMN2 | |
| SCHEMBL7053234 | 0.72 | PDE4A (0.50) | PDE4APDE4BPDE4CPDE4DSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0901482-B1 | BENZOFURAN CARBOXAMIDES AND THEIR THERAPEUTIC USE | DARWIN DISCOVERY LTD (GB) | 2003-05-02 | — | — | EP | disclosed |
| US-5925636-A | Benzofuran carboxamides and their therapeutic use | DARWIN DISCOVERY LIMITED (GB) | 1999-07-20 | — | — | US | disclosed |
| EP-0901482-A1 | BENZOFURAN CARBOXAMIDES AND THEIR THERAPEUTIC USE | Darwin Discovery Limited (GB) | 1999-03-17 | — | — | EP | disclosed |
| WO-1997044337-A1 | BENZOFURAN CARBOXAMIDES AND THEIR THERAPEUTIC USE | DARWIN DISCOVERY LIMITED (GB) | 1997-11-27 | — | — | WO | disclosed |