Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 1/20 | 0.51 |
| ▸ | THRA | P10827 | 8/20 | 0.47 |
| ▸ | THRB | P10828 | 8/20 | 0.47 |
| ▸ | BCL2 | P10415 | 2/20 | 0.45 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.42 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7052042 | 0.91 | THRA (0.59) | NR3C1THRATHRBBCL2MCL1 | |
| SCHEMBL7051611 | 0.88 | NR3C1 (0.51) | NR3C1THRATHRBBCL2MCL1 | |
| SCHEMBL7048724 | 0.88 | NR3C1 (0.65) | NR3C1THRATHRBBCL2MCL1 | |
| SCHEMBL7053938 | 0.87 | NR3C1 (0.67) | NR3C1THRATHRB | |
| SCHEMBL7052898 | 0.86 | THRA (0.48) | NR3C1THRATHRBBCL2MCL1 | |
| SCHEMBL7051459 | 0.84 | NR3C1 (0.59) | NR3C1THRATHRB | |
| SCHEMBL7048799 | 0.84 | NR3C1 (0.47) | NR3C1THRATHRBBCL2MCL1 | |
| SCHEMBL7053962 | 0.80 | NR3C1 (0.46) | NR3C1THRATHRBBCL2MCL1 | |
| SCHEMBL7053960 | 0.79 | NR3C1 (0.62) | NR3C1THRATHRB | |
| SCHEMBL5631737 | 0.79 | NR3C1 (0.81) | NR3C1THRATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1102739-B1 | GLUCOCORTICOID AND THYROID HORMONE RECEPTOR LIGANDS FOR THE TREATMENT OF METABOLIC DISORDERS | KAROBIO AB (SE) | 2003-04-23 | — | — | EP | disclosed |
| US-6492424-B1 | Glucocorticoid and thyroid hormone receptor ligands for the treatment of metabolic disorders | KARO BIO AB (SE) | 2002-12-10 | — | — | US | disclosed |
| EP-1102739-A1 | GLUCOCORTICOID AND THYROID HORMONE RECEPTOR LIGANDS FOR THE TREATMENT OF METABOLIC DISORDERS | KARO BIO AB (SE) | 2001-05-30 | — | — | EP | disclosed |
| WO-2000007972-A1 | GLUCOCORTICOID AND THYROID HORMONE RECEPTOR LIGANDS FOR THE TREATMENT OF METABOLIC DISORDERS | KARO BIO AB (SE) | 2000-02-17 | — | — | WO | disclosed |