Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 6/20 | 0.61 |
| ▸ | MTNR1B | P49286 | 6/20 | 0.61 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.52 |
| ▸ | HTR1B | P28222 | 8/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 2/20 | 0.46 |
| ▸ | HTR2C | P28335 | 1/20 | 0.46 |
| ▸ | HTR2B | P41595 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 7/20 | 0.45 |
| ▸ | HTR1D | P28221 | 7/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7056049 | 0.87 | MTNR1A (0.61) | MTNR1AMTNR1BTRPV1HTR2AHTR2C | |
| SCHEMBL24358705 | 0.78 | HTR1B (0.60) | MTNR1AMTNR1BHTR1BHTTHTR2A | |
| SCHEMBL7051639 | 0.78 | MTNR1A (0.52) | MTNR1AMTNR1BTRPV1HTR1BHTT | |
| SCHEMBL7055753 | 0.76 | MTNR1A (0.51) | MTNR1AMTNR1BTRPV1HTR2BMAPT | |
| SCHEMBL7055939 | 0.76 | MTNR1A (1.00) | MTNR1AMTNR1BTRPV1HTR2AHTR2C | |
| SCHEMBL9671722 | 0.76 | MTNR1A (1.00) | MTNR1AMTNR1BTRPV1HTR2AHTR2C | |
| SCHEMBL9671286 | 0.76 | MTNR1A (1.00) | MTNR1AMTNR1BTRPV1HTR2AHTR2C | |
| SCHEMBL7057923 | 0.76 | MTNR1A (0.44) | MTNR1AMTNR1BTRPV1HTR2C | |
| SCHEMBL7051405 | 0.74 | MTNR1A (0.78) | MTNR1AMTNR1BTRPV1HTR2BCYP1A2 | |
| SCHEMBL7052855 | 0.74 | MTNR1A (0.55) | MTNR1AMTNR1BTRPV1HTTHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0656209-B1 | Melatonin derivatives for use in treating desynchronization disorders | LILLY CO ELI (US) | 2003-05-07 | — | — | EP | disclosed |
| EP-0655243-B1 | Melatonin derivatives for use in treating sleep disorders | LILLY CO ELI (US) | 2002-08-21 | — | — | EP | disclosed |
| US-6180657-B1 | SLEEP DISORDERS | ELI LILLY AND COMPANY | 2001-01-30 | — | — | US | disclosed |
| US-5654325-A | Melatonin derivatives for use in treating sleep disorders | ELI LILLY AND COMPANY (US) | 1997-08-05 | — | — | US | disclosed |
| EP-0748627-A2 | Melatonin agonists for use in the treatment of benign prostatic hyperplasia | ELI LILLY AND COMPANY (US) | 1996-12-18 | — | — | EP | disclosed |
| EP-0656209-A2 | Melatonin derivatives for use in treating desynchronization disorders | ELI LILLY AND COMPANY (US) | 1995-06-07 | — | — | EP | disclosed |
| EP-0655243-A2 | Melatonin derivatives for use in treating sleep disorders | ELI LILLY AND COMPANY (US) | 1995-05-31 | — | — | EP | disclosed |
| US-4997845-A | β-alkylmelatonins as ovulation inhibitors | ELI LILLY AND COMPANY (US) | 1991-03-05 | — | — | US | disclosed |